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CAS 38027-95-1

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(Sar1,Ala8)-Angiotensin II

Description:
(Sar1,Ala8)-Angiotensin II, with the CAS number 38027-95-1, is a synthetic analog of the naturally occurring peptide hormone angiotensin II, which plays a crucial role in regulating blood pressure and fluid balance. This compound is characterized by the substitution of sarcosine (Sar) at the first position and alanine (Ala) at the eighth position of the angiotensin II sequence, which alters its biological activity and receptor binding properties. The modifications enhance its stability and affinity for angiotensin receptors, making it a valuable tool in pharmacological research. Typically, it exhibits potent vasoconstrictive properties and influences various physiological processes, including aldosterone secretion and thirst stimulation. The compound is often utilized in studies related to cardiovascular physiology and pathophysiology, particularly in understanding hypertension and heart failure mechanisms. Its structural modifications also allow for the exploration of receptor interactions and the development of potential therapeutic agents targeting the renin-angiotensin system.
Formula:C43H67N13O10
InChI:InChI=1/C43H67N13O10/c1-7-24(4)35(40(63)53-31(19-27-20-47-22-49-27)41(64)56-17-9-11-32(56)38(61)50-25(5)42(65)66)55-37(60)30(18-26-12-14-28(57)15-13-26)52-39(62)34(23(2)3)54-36(59)29(51-33(58)21-46-6)10-8-16-48-43(44)45/h12-15,20,22-25,29-32,34-35,46,57H,7-11,16-19,21H2,1-6H3,(H,47,49)(H,50,61)(H,51,58)(H,52,62)(H,53,63)(H,54,59)(H,55,60)(H,65,66)(H4,44,45,48)/t24-,25-,29-,30-,31-,32-,34-,35-/m0/s1
SMILES:CC[C@H](C)[C@@H](C(=N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=N[C@@H](C)C(=O)O)O)O)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](C(C)C)N=C([C@H](CCCNC(=N)N)N=C(CNC)O)O)O)O
Synonyms:
  • Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OH
  • N-methylglycyl-N~5~-(diaminomethylidene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-alanine
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  • (Sar 1,Ala8)-Angiotensin II
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    (Sar 1,Ala8)-Angiotensin II

    CAS:
    <p>Angiotensin II is a peptide hormone that is involved in the regulation of blood pressure and fluid and electrolyte balance. It also acts as a vasoconstrictor by binding to angiotensin receptors on vascular smooth muscle cells. Angiotensin II is produced from angiotensin I by the action of renin. The high-resolution linear reformulating (HRLR) technique is used to estimate the spectrum and parameters of this molecule. This technique uses iterative methods for estimating the frequency response function and parameters for each frequency, including nonlinear ones. HRLR has been shown to be an accurate estimator with a frequency range from 0 to 10 kHz, which has not been achieved with other techniques.</p>
    Formula:C43H67N13O10
    Purity:Min. 95 Area-%
    Color and Shape:Powder
    Molecular weight:926.07 g/mol

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