Melphalan flufenamide, with the CAS number 380449-51-4, is a synthetic compound that belongs to the class of alkylating agents, specifically designed for targeted cancer therapy. It is a prodrug of melphalan, which means it is converted into its active form within the body. This compound exhibits a unique mechanism of action by selectively delivering the cytotoxic agent to cancer cells, thereby minimizing damage to healthy tissues. Melphalan flufenamide is characterized by its ability to form DNA cross-links, leading to cell cycle arrest and apoptosis in rapidly dividing cells, particularly in multiple myeloma and other hematological malignancies. Its pharmacokinetic properties allow for improved solubility and bioavailability compared to traditional melphalan. Additionally, it has been studied for its potential to overcome resistance mechanisms commonly seen in cancer treatment. As with many chemotherapeutic agents, its use may be associated with side effects, necessitating careful monitoring during treatment. Overall, melphalan flufenamide represents a promising advancement in targeted cancer therapies.

Melphalan Flufenamide

380449-51-4: Melphalan flufenamide, with the CAS number 380449-51-4, is a synthetic compound that belongs to the class of alkylating agents, specifically designed for targeted cancer therapy. It is a prodrug of melphalan, which means it is converted into its active form within the body. This compound exhibits a unique mechanism of action by selectively delivering the cytotoxic agent to cancer cells, thereby minimizing damage to healthy tissues. Melphalan flufenamide is characterized by its ability to form DNA cross-links, leading to cell cycle arrest and apoptosis in rapidly dividing cells, particularly in multiple myeloma and other hematological malignancies. Its pharmacokinetic properties allow for improved solubility and bioavailability compared to traditional melphalan. Additionally, it has been studied for its potential to overcome resistance mechanisms commonly seen in cancer treatment. As with many chemotherapeutic agents, its use may be associated with side effects, necessitating careful monitoring during treatment. Overall, melphalan flufenamide represents a promising advancement in targeted cancer therapies.

Ethyl (S)-2-((S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanamido)-3-(4-fluorophenyl)propanoate

Melflufen, a dipeptide prodrug of Melphalan, is an alkylating agent with strong antitumor activity in MM, causing DNA damage and cytotoxicity.

CAS 380449-51-4

Melphalan Flufenamide

Ethyl (S)-2-((S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanamido)-3-(4-fluorophenyl)propanoate

Ref: 54-PC1006507

Melflufen

Ref: TM-T33281