CAS 380449-54-7

Ethyl (S)-2-((S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanamido)-3-(4-fluorophenyl)propanoate hydrochloride

CAS: 380449-54-7

Ethyl (S)-2-((S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanamido)-3-(4-fluorophenyl)propanoate hydrochloride

Purity: 98%

Molecular weight: 534.89g/mol

Ref: 54-PC1007760

Melflufen hydrochloride

CAS: 380449-54-7

Melflufen HCl: prodrug of Melphalan, has antitumor and antiangiogenic effects, causes DNA damage in MM cells.

Formula: C₂₄H₃₁Cl₃FN₃O₃

Color and Shape: Solid

Molecular weight: 534.88

Ref: TM-T40478

Melflufen hydrochloride

CAS: 380449-54-7

Melflufen hydrochloride is a peptide-conjugated alkylating agent, which is a small molecule derived from the combination of melphalan and a peptide moiety. Its design targets malignant cells through an innovative mechanism involving enhanced lipophilicity, allowing the compound to more efficiently penetrate cell membranes. Once inside the cell, the peptide linkage is cleaved by aminopeptidases, predominantly in cancer cells due to their overexpression of such enzymes. This cleavage releases active melphalan, which then forms covalent bonds with DNA, leading to crosslinking and subsequent interruption of DNA replication and transcription, ultimately inducing cell apoptosis.The primary applications of Melflufen hydrochloride are in oncology, specifically targeting hematological malignancies such as multiple myeloma. Its targeted delivery system aims to minimize the systemic toxicity commonly associated with conventional alkylating agents, offering a potentially improved therapeutic index. Researchers are exploring its efficacy in various clinical settings to better understand its utility and refine its application in personalized medicine approaches for cancer patients.

Formula: C₂₄H₃₁Cl₃FN₃O₃

Purity: Min. 95%

Molecular weight: 534.9 g/mol

Ref: 3D-FQA44954