CAS 380843-75-4: Bosutinib

Description: Bosutinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of chronic myelogenous leukemia (CML). It selectively inhibits the BCR-ABL fusion protein, which is responsible for the proliferation of cancer cells in CML. Bosutinib has a molecular formula that reflects its complex structure, featuring multiple functional groups that contribute to its pharmacological activity. The compound is characterized by its ability to inhibit not only BCR-ABL but also other kinases, which may lead to a broader spectrum of effects. It is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Common side effects associated with bosutinib include gastrointestinal disturbances, hematologic abnormalities, and liver enzyme elevations. Its efficacy and safety profile make it a valuable option in the therapeutic landscape for patients with resistant or intolerant forms of CML. As with all medications, monitoring for adverse effects and drug interactions is essential during treatment.

Formula: C₂₆H₂₉Cl₂N₅O₃

InChI: InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)

InChI key: InChIKey=UBPYILGKFZZVDX-UHFFFAOYSA-N

SMILES: N#CC1=CN=C2C=C(OCCCN3CCN(C)CC3)C(OC)=CC2=C1NC4=CC(OC)=C(Cl)C=C4Cl

Synonyms:

• 3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-Methoxyphenyl)amino]-6-Methoxy-7-[3-(4-Methyl-1-piperazinyl)propoxy]-
• 4-[(2,4-Dichloro-5-Methoxyphenyl)Amino]-6-Methoxy-7-[3-(4-Methylpiperazin-1-Yl)Propoxy]Quinoline-3-Carbonitrile
• 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
• Bosulif
• Kin 001-160
• Sk 606
• Ski-606
• Bosutinib

Bosutinib

CAS: 380843-75-4

Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl …

• Formula: C₂₆H₂₉Cl₂N₅O₃
• Purity: 98.98% - 99.9%
• Color and Shape: Yellowish-Orange Or Pink To Brownish Solid Solid Powder
• Molecular weight: 530.45

Bosutinib

CAS: 380843-75-4

• Formula: C₂₆H₂₉Cl₂N₅O₃
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 530.4462

Bosutinib

CAS: 380843-75-4

• Formula: C₂₆H₂₉Cl₂N₅O₃
• Color and Shape: Pale Yellow Solid
• Molecular weight: 530.45

Bosutinib

CAS: 380843-75-4

• Purity: ≥98%
• Molecular weight: 530.45g/mol

Bosutinib

CAS: 380843-75-4

• Formula: C₂₆H₂₉Cl₂N₅O₃
• Purity: (HPLC) ≥ 98.0%
• Color and Shape: Light yellow to yellow powder
• Molecular weight: 530.45

Bosutinib

CAS: 380843-75-4

• Formula: C₂₆H₂₉Cl₂N₅O₃
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 530.45

Bosutinib

CAS: 380843-75-4

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₆H₂₉Cl₂N₅O₃
• Color and Shape: Almost white to yellow, Crystalline powder
• Molecular weight: 530.45

Bosutinib Impurity 14

CAS: 380843-75-4918639-08-4

• Formula: C₁₀H₈Cl₂N₂O₂
• Color and Shape: Pale Yellow Solid
• Molecular weight: 259.09

Bosutinib

CAS: 380843-75-4

• Purity: 99%
• Molecular weight: 530.450012207031

Bosutinib

CAS: 380843-75-4

Inhibitor of Abl and Src kinases; anti-proliferative; antineoplasticÂ

• Formula: C₂₆H₂₉Cl₂N₅O₃
• Purity: Min. 95%
• Color and Shape: Off-White Powder
• Molecular weight: 530.45 g/mol

1-Methyl-4-propylpiperazine Bosutinib

CAS: 380843-75-4

Applications 4-((2,4-Dichloro-5-methoxyphenyl)(3-(4-methylpiperazin-1-yl)propyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile is an impurity of Bosutinib (B676095). It is a COVID19-related research product.

• Formula: C₃₄H₄₅Cl₂N₇O₃
• Color and Shape: Neat
• Molecular weight: 670.672

5,6-Dihydroxy-Des(dimethoxy) Bosutinib

CAS: 380843-75-4

• Formula: C₂₄H₂₅Cl₂N₅O₃
• Color and Shape: Neat
• Molecular weight: 502.393