CAS 380843-75-4

Bosutinib

Description:

Bosutinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of chronic myelogenous leukemia (CML). It selectively inhibits the BCR-ABL fusion protein, which is responsible for the proliferation of cancer cells in CML. Bosutinib has a molecular formula that reflects its complex structure, featuring multiple functional groups that contribute to its pharmacological activity. The compound is characterized by its ability to inhibit not only BCR-ABL but also other kinases, which may lead to a broader spectrum of effects. It is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Common side effects associated with bosutinib include gastrointestinal disturbances, hematologic abnormalities, and liver enzyme elevations. Its efficacy and safety profile make it a valuable option in the therapeutic landscape for patients with resistant or intolerant forms of CML. As with all medications, monitoring for adverse effects and drug interactions is essential during treatment.

Formula: C₂₆H₂₉Cl₂N₅O₃

InChI: InChI=1/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)

InChI key: InChIKey=UBPYILGKFZZVDX-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(OCCCN3CCN(C)CC3)C(OC)=C2)N=CC1C#N)C4=CC(OC)=C(Cl)C=C4Cl

Synonyms:

• 3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-Methoxyphenyl)amino]-6-Methoxy-7-[3-(4-Methyl-1-piperazinyl)propoxy]-
• 4-[(2,4-Dichloro-5-Methoxyphenyl)Amino]-6-Methoxy-7-[3-(4-Methylpiperazin-1-Yl)Propoxy]Quinoline-3-Carbonitrile
• 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
• Bosulif
• Kin 001-160
• Sk 606
• Ski-606
• Bosutinib
• Bosutinib for research

Bosutinib

CAS: 380843-75-4

Formula: C₂₆H₂₉Cl₂N₅O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 530.4462

Ref: IN-DA00BXOO

Bosutinib

CAS: 380843-75-4

Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.

Formula: C₂₆H₂₉Cl₂N₅O₃

Purity: 98.98% - 99.9%

Color and Shape: Yellowish-Orange Or Pink To Brownish Solid Solid Powder

Molecular weight: 530.45

Ref: TM-T0152

Bosutinib

CAS: 380843-75-4

Formula: C₂₆H₂₉Cl₂N₅O₃

Color and Shape: Pale Yellow Solid

Molecular weight: 530.45

Ref: 4Z-B-641

Bosutinib

CAS: 380843-75-4

Bosutinib

Purity: ≥98%

Molecular weight: 530.45g/mol

Ref: 54-BUP15630

Bosutinib

CAS: 380843-75-4

Formula: C₂₆H₂₉Cl₂N₅O₃

Purity: (HPLC) ≥ 98.0%

Color and Shape: Light yellow to yellow powder

Molecular weight: 530.45

Ref: 7W-GP8650

Bosutinib

CAS: 380843-75-4

Formula: C₂₆H₂₉Cl₂N₅O₃

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 530.45

Ref: 3B-B4824

Bosutinib Impurity 14

CAS: 380843-75-4, 918639-08-4

Formula: C₁₀H₈Cl₂N₂O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 259.09

Ref: 4Z-B-6418

Bosutinib

CAS: 380843-75-4

Inhibitor of Abl and Src kinases; anti-proliferative; antineoplasticÂ

Formula: C₂₆H₂₉Cl₂N₅O₃

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 530.45 g/mol

Ref: 3D-FB19002

Bosutinib

CAS: 380843-75-4

Purity: 99%

Molecular weight: 530.4500122

Ref: 10-F794031

1-Methyl-4-propylpiperazine Bosutinib

Controlled Product

CAS: 380843-75-4

Applications 4-((2,4-Dichloro-5-methoxyphenyl)(3-(4-methylpiperazin-1-yl)propyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile is an impurity of Bosutinib (B676095). It is a COVID19-related research product.

Formula: C₃₄H₄₅Cl₂N₇O₃

Color and Shape: Neat

Molecular weight: 670.672

Ref: TR-D424530

5,6-Dihydroxy-Des(dimethoxy) Bosutinib

Controlled Product

CAS: 380843-75-4

Formula: C₂₄H₂₅Cl₂N₅O₃

Color and Shape: Neat

Molecular weight: 502.393

Ref: TR-D676100

Bosutinib

CAS: 380843-75-4

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₆H₂₉Cl₂N₅O₃

Molecular weight: 529.16475

Ref: 45-1076180