CAS 380899-24-1

N-[[(2S)-1-[[5-(4-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide

Description:

N-[[(2S)-1-[[5-(4-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide, with CAS number 380899-24-1, is a synthetic organic compound characterized by its complex structure, which includes a benzofuran moiety, a piperidine ring, and a thiazole derivative. This compound is notable for its potential pharmacological properties, often explored in the context of medicinal chemistry and drug development. The presence of the fluorophenyl group may enhance its biological activity and lipophilicity, while the thiazole and benzofuran components contribute to its overall stability and reactivity. The stereochemistry indicated by the (2S) designation suggests specific spatial arrangements that can influence its interaction with biological targets. As a result, this compound may exhibit unique mechanisms of action, making it a subject of interest in therapeutic research, particularly in areas such as oncology or neurology. Its solubility, stability, and bioavailability are critical factors that would be evaluated in further studies to assess its viability as a pharmaceutical agent.

Formula: C₂₆H₂₄FN₃O₃S

InChI: InChI=1S/C26H24FN3O3S/c1-16-29-23(24(34-16)17-8-10-18(27)11-9-17)26(32)30-13-3-2-5-19(30)15-28-25(31)21-6-4-7-22-20(21)12-14-33-22/h4,6-12,14,19H,2-3,5,13,15H2,1H3,(H,28,31)/t19-/m0/s1

InChI key: InChIKey=ZJXIUGNEAIHSBI-IBGZPJMESA-N

SMILES: C(=O)(C1=C(SC(C)=N1)C2=CC=C(F)C=C2)N3[C@H](CNC(=O)C4=C5C(OC=C5)=CC=C4)CCCC3

Synonyms:

• (S)-2-[[[(Benzofuran-4-yl)carbonyl]amino]methyl]-1-[[2-methyl-5-(4-fluorophenyl)-4-thiazolyl]carbonyl]piperidine
• 4-Benzofurancarboxamide, N-[[(2S)-1-[[5-(4-fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-
• SB 649868
• N-[[(2S)-1-[[5-(4-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide
• GSK 649868

N-[[(2S)-1-[[5-(4-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide

CAS: 380899-24-1

Formula: C₂₆H₂₄FN₃O₃S

Purity: %

Color and Shape: Solid

Molecular weight: 477.5505

Ref: IN-DA003A2W

(S)-N-((1-(5-(4-Fluorophenyl)-2-Methylthiazole-4-Carbonyl)Piperidin-2-Yl)Methyl)Benzofuran-4-Carboxamide

CAS: 380899-24-1

(S)-N-((1-(5-(4-Fluorophenyl)-2-Methylthiazole-4-Carbonyl)Piperidin-2-Yl)Methyl)Benzofuran-4-Carboxamide

Purity: 99+%

Molecular weight: 477.55g/mol

Ref: 54-PC108619

SB-649868

CAS: 380899-24-1

SB-649868

Purity: ≥98%

Molecular weight: 477.55g/mol

Ref: 54-BUP09104

SB-649868

CAS: 380899-24-1

SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).

Formula: C₂₆H₂₄FN₃O₃S

Purity: 99.53%

Color and Shape: Solid

Molecular weight: 477.55

Ref: TM-T5498

SB-649868

CAS: 380899-24-1

SB-649868 is a drug in clinical development for the treatment of sleep-wake disorders. It is a potent and selective allosteric modulator of the GABAA receptor, with a profile that includes high affinity for the α1β2γ2 subtype. SB-649868 has been shown to increase slow wave sleep and delta power during wakefulness in healthy human subjects. SB-649868 has also been shown to have no effect on blood pressure or heart rate at clinically relevant doses, suggesting reduced risk for cardiovascular side effects.
SB-649868 was well tolerated in preclinical studies, without serious adverse events observed.

Formula: C₂₆H₂₄FN₃O₃S

Purity: Min. 95%

Molecular weight: 477.55 g/mol

Ref: 3D-FQA89924