CAS 380917-97-5

Perampanel

Description:

Perampanel is a pharmaceutical compound primarily used as an antiepileptic drug. It is classified as a non-competitive antagonist of the AMPA receptor, which plays a crucial role in excitatory neurotransmission in the central nervous system. The chemical formula of Perampanel is C18H18F2N2O2, and it features a distinctive structure that includes a phenyl ring and a pyridine moiety. This compound is known for its ability to reduce seizure frequency in patients with epilepsy, particularly in those with partial-onset seizures. Perampanel is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its pharmacokinetics can be influenced by factors such as age, weight, and concomitant medications. Common side effects may include dizziness, fatigue, and irritability. As with any medication, it is essential for patients to consult healthcare professionals for personalized advice and monitoring while using Perampanel.

Formula: C₂₃H₁₅N₃O

InChI: InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H

InChI key: InChIKey=PRMWGUBFXWROHD-UHFFFAOYSA-N

SMILES: O=C1C(=CC(=CN1C2=CC=CC=C2)C3=CC=CC=N3)C4=C(C#N)C=CC=C4

Synonyms:

• 2-(1′,6′-Dihydro-6′-oxo-1′-phenyl[2,3′-bipyridin]-5′-yl)benzonitrile
• 3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one
• 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
• Benzonitrile, 2-(1′,6′-dihydro-6′-oxo-1′-phenyl[2,3′-bipyridin]-5′-yl)-
• E 2007
• Er 155055-90
• Fycompa
• Perampanel

Perampanel

CAS: 380917-97-5

Formula: C₂₃H₁₅N₃O

Color and Shape: Off-White Solid

Molecular weight: 349.39

Ref: 4Z-P-181001

Perampanel

Controlled Product

CAS: 380917-97-5

Applications Perampanel is a novel, noncompetitive AMPA receptor antagonist for the treatment of epilepsy. Also in the treatment of primary generalized tonic-clonic seizures in idiopathic generalized epilepsy. Perampanel is a selective non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist that reduces neuronal excitation (1,2,3,4).
References (1) Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013)(2) Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011)(3) Franco, V., et al.: Ther Drug Monit. 38, 744 (2016) (4) Rudzinski, L. A., et al.: J Investig Med. 64, 1087 (2016)

Formula: C₂₃H₁₅N₃O

Color and Shape: Light Yellow

Molecular weight: 349.38

Ref: TR-P285520

Perampanel

Controlled Product

CAS: 380917-97-5

Perampanel is an adjunctive antiepileptic drug that acts as a non-competitive antagonist at the AMPA receptor. The baseline matrix effect of perampanel was found to be statistically significant, with no significant drug interactions observed. In clinical trials, perampanel was found to reduce seizure frequency in patients with partial onset seizures, with a median reduction of 28% from baseline. Perampanel was well tolerated and stable doses were achieved in most patients.

Formula: C₂₃H₁₅N₃O

Purity: Min. 99 Area-%

Color and Shape: White Powder

Molecular weight: 349.38 g/mol

Ref: 3D-FP65127

Perampanel-13C6

Controlled Product

CAS: 380917-97-5

Formula: C₆C₁₇H₁₅N₃O

Color and Shape: Neat

Molecular weight: 355.341

Ref: TR-P285517