CAS 3810-74-0

Streptomycin sulfate

Description:

Streptomycin sulfate is an aminoglycoside antibiotic derived from the bacterium Streptomyces griseus. It is primarily used to treat various bacterial infections, particularly those caused by Mycobacterium tuberculosis, making it significant in tuberculosis therapy. The compound is characterized by its ability to inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit, which disrupts the translation process. Streptomycin sulfate is a white to slightly yellow crystalline powder that is soluble in water, which facilitates its administration via injection. It has a molecular formula that reflects its complex structure, including multiple amino and hydroxyl groups. The sulfate form enhances its solubility and stability. Common side effects include ototoxicity and nephrotoxicity, necessitating careful monitoring during treatment. Streptomycin sulfate is also notable for its role in the development of antibiotic resistance, underscoring the importance of judicious use in clinical settings. Overall, it remains a critical agent in the arsenal against certain bacterial infections, particularly in the context of multidrug-resistant strains.

Formula: C₂₁H₃₉N₇O₁₂H₂O₄S

InChI: InChI=1S/C21H39N7O12.H2O4S/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;1-5(2,3)4/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);(H2,1,2,3,4)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+;/m0./s1

InChI key: InChIKey=CFCMMYICHMLDCC-RMIBZTJPSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@@H]2[C@@H](NC(=N)N)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]2O)O[C@@H](C)[C@@]1(C=O)O)[C@H]3[C@@H](NC)[C@H](O)[C@@H](O)[C@H](CO)O3

Synonyms:

• 1,1'-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (1:1)
• 2,2'-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (2:3)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-deoxy-2-(methylamino)-α-<smallcap>L</smallcap>-glucopyranosyl-(1→2)-O-5-deoxy-3-C-formyl-α-<smallcap>L</span>-lyxofuranosyl-(1→4)-N,N′-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-deoxy-2-(methylamino)-α-<smallcap>L</smallcap>-glucopyranosyl-(1→2)-O-5-deoxy-3-C-formyl-α-<smallcap>L</span>-lyxofuranosyl-(1→4)-N¹,N³-bis(aminoiminomethyl)-, sulfate (2:3)
• Ag Streptomycin
• Agri-Strep
• Agrimycin 17
• Agrimycin sulfate
• Ambistryn
• Ambistryn S
• D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1→4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
• D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3)
• FireWall (pesticide)
• Flare 72SP
• Hortocyna
• KeyStrepto
• N'',N'''''-[(1R,2R,3S,4R,5R,6S)-4-({(2xi)-5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-threo-pentofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (salt)
• N'',N'''''-[(1S,2S,3R,4S,5S,6R)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-formyl-α-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (2:3) (salt)
• O-2-Deoxy-2-(Methylamino)-Alpha-L-Glucopyranosyl-(1->2)-O-5-Deoxy-3-C-Formyl-Alpha-L-Lyxofuranosyl-(1->4)-N,N'-Bis(Aminoiminomethyl)-Streptamine Sulfate (2:3)
• O-2-Deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-c-formyl-α-L-lyxofuranosyl-(1→4)-N,N'-bis(aminoiminomethyl)-D-streptamine sulfate (2:3)
• Plantomycin
• Strepto
• Streptobrettin
• Streptomycin A sulfate
• Streptomycin Sesquisulfate
• Streptomycin Sulfate Sterile
• Streptomycin sesquisulphate
• Streptomycin sulphate
• Streptomycin, sulfate (2:3) (salt)
• Streptomycinsulfat
• Streptonex
• Strycin
• Sulfate de streptomycine
• Sulfato De Estreptomicina
• Vetstrep

Streptomycin Sulfate

CAS: 3810-74-0

Formula: C₂₁H₃₉N₇O₁₂(H₂SO₄)

Molecular weight: 581.6 : 3/2(98.1)

Ref: ST-EA-CP-S124001

Streptomycin Sulfate

Controlled Product

CAS: 3810-74-0

Applications Streptomycin Sulfate is an antibiotic produced by aerobic fermentation. Antibacterial (tuberculostatic).
References Weiss, et al.: Antibiot. Chemother., 7, 374 (1957), Umezawa, et al.: J. Antibiot., 27, 997 (1974), Mossa, J., et al.: Anal. Profiles Drug Subs., 16, 507 (1986),

Formula: C₂₁H₃₉N₇O₁₂·3H₂O₄S

Color and Shape: Neat

Molecular weight: 1457.38

Ref: TR-S687500

Streptomycin sulfate, Antibiotic for Culture Media Use Only

CAS: 3810-74-0

Streptomycin sulfate is an antibiotic that inhibits the growth of bacteria by binding to the ribosomal subunit and interfering with protein synthesis. It is used in culture media for the production of human antibodies as well as in drug therapy for methicillin-resistant staphylococcus. Streptomycin sulfate has a high specific activity and low sensitivity, but it also has a low solubility in water. The active form of streptomycin sulfate is streptomycin A, which is produced by the addition of a phenyl ring to neomycin sulfate. In plant roots, streptomycin sulfate inhibits cyanogenic glycosides from being hydrolyzed into hydrogen cyanide (HCN) and benzaldehyde.

Formula: C₄₂H₈₄N₁₄O₃₆S₃

Molecular weight: 1,457.40 g/mol

Ref: 3D-S-8500

Streptomycin sulfate

CAS: 3810-74-0

Inhibitor of protein synthesis; aminoglycoside

Formula: (C₂₁H₃₉N₇O₁₂)₂•(H₂SO₄)₃

Purity: Min. 720 Iu/Mg

Color and Shape: White Off-White Powder

Molecular weight: 1,457.39 g/mol

Ref: 3D-AS01530

Streptomycin Sulphate for tissue culture

CAS: 3810-74-0

Formula: (C₂₁H₃₉N₇O₁₂)₂·3H₂SO₄

Color and Shape: White to off - white, Crystalline powder, Clear, Pale yellow

Molecular weight: 1457.38

Ref: SR-62463

Streptomycin Sulphate (STM)

CAS: 3810-74-0

Formula: (C₂₁H₃₉N₇O₁₂)₂·3H₂SO₄

Color and Shape: White to off - white, Crystalline powder, Clear, Pale yellow

Molecular weight: 1457.38

Ref: SR-91014