CAS 3817-05-8

2-(chloromethyl)quinazolin-4(1H)-one

Description:

2-(Chloromethyl)quinazolin-4(1H)-one is a chemical compound characterized by its quinazolinone structure, which features a fused bicyclic system containing both a benzene and a pyrimidine ring. This compound typically exhibits a chloromethyl group at the 2-position of the quinazolinone, which can influence its reactivity and potential applications in medicinal chemistry. The presence of the chlorine atom can enhance electrophilic properties, making it a useful intermediate in organic synthesis. The compound is often studied for its biological activity, including potential antimicrobial and anticancer properties, due to the structural motifs common in bioactive molecules. Additionally, it may be soluble in organic solvents, and its stability can vary depending on environmental conditions such as temperature and pH. As with many chemical substances, safety precautions should be taken when handling it, as it may pose health risks if ingested or inhaled. Overall, 2-(chloromethyl)quinazolin-4(1H)-one is of interest in both synthetic and pharmaceutical chemistry.

Formula: C₉H₇ClN₂O

InChI: InChI=1/C9H7ClN2O/c10-5-8-11-7-4-2-1-3-6(7)9(13)12-8/h1-4H,5H2,(H,11,12,13)

SMILES: c1ccc2c(c1)c(nc(CCl)n2)O

Synonyms:

• 2-(chloromethyl)quinazolin-4(3H)-one
• 4(3H)-quinazolinone, 2-(chloromethyl)-
• 4-Quinazolinol, 2-(Chloromethyl)-

2-(Chloromethyl)-4-hydroxyquinazoline

CAS: 3817-05-8

Formula: C₉H₇ClN₂O

Purity: 97%

Color and Shape: Solid

Molecular weight: 194.6177

Ref: IN-DA003F0F

2-(Chloromethyl)quinazolin-4(3H)-one

CAS: 3817-05-8

2-(Chloromethyl)quinazolin-4(3H)-one

Purity: 97%

Molecular weight: 194.62g/mol

Ref: 54-OR309404

2-(Chloromethyl)-4-hydroxyquinazoline

CAS: 3817-05-8

2-(Chloromethyl)-4-hydroxyquinazoline

Formula: C₉H₇ClN₂O

Purity: ≥95%

Color and Shape: white crystalline powder

Molecular weight: 194.62g/mol

Ref: 54-OR4920

2-(Chloromethyl)quinazolin-4(3H)-one

CAS: 3817-05-8

Formula: C₉H₇ClN₂O

Purity: 95%

Color and Shape: Solid

Molecular weight: 194.62

Ref: 10-F233522

2-(Chloromethyl)quinazolin-4(3H)-one

CAS: 3817-05-8

2-(Chloromethyl)quinazolin-4(3H)-one is a quinazolinone antibacterial agent. It has been shown to have activity against Staphylococcus species, including methicillin-resistant strains. 2-(Chloromethyl)quinazolin-4(3H)-one binds to the bacterial ribosome and inhibits protein synthesis, leading to cell death. The molecule is nucleophilic, which allows it to react with the ribosomal RNA of bacteria. This drug has also been shown to be cytotoxic in vitro and in vivo against human tumor cells. 2-(Chloromethyl)quinazolin-4(3H)-one has been modified by attaching a benzoyl group at the para position on the phenyl ring or by substituting one of its hydrogens with a methyl group at the para position on the phenyl ring. These modifications have resulted in increased anticancer activity for this

Formula: C₉H₇ClN₂O

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 194.62 g/mol

Ref: 3D-FC128221