CAS 38176-02-2

(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride

Description:

The chemical substance known as "(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride" with the CAS number 38176-02-2 is a quaternary ammonium compound characterized by its complex structure, which includes a cyano group, multiple methoxy substituents, and a hexyl chain. This compound exhibits properties typical of quaternary ammonium salts, such as solubility in polar solvents and potential biological activity. The presence of methoxy groups suggests that it may have enhanced lipophilicity, which can influence its interaction with biological membranes. Additionally, the cyano group may impart unique reactivity and stability characteristics. As a chloride salt, it is likely to be ionic in nature, contributing to its solubility in aqueous environments. The specific stereochemistry indicated by the "(+)" designation suggests that it may exhibit chiral properties, which can affect its pharmacological profile and interactions in biological systems. Overall, this compound's unique structural features may make it of interest in medicinal chemistry and pharmacology.

Formula: C₂₇H₃₈N₂O₄·ClH

InChI: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/t27-;/m1./s1

InChI key: InChIKey=DOQPXTMNIUCOSY-HZPIKELBSA-N

SMILES: [C@](CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C=C2.Cl

Synonyms:

• (+)-Verapamil hydrochloride
• (2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride (1:1)
• (R)-Verapamil hydrochloride
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, hydrochloride (1:1), (αR)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (R)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (αR)-
• Dexverapamil monohydrochloride
• Lu 33925
• NSC 632821
• (+)-(3-Cyano-3-(3,4-dimethoxyphenyl)hex-6-yl)(5,6-dimethoxyphenethyl)methylammonium chloride
• R(+)-Verapamil hydrate monohydrochloride
• Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (aR)- (9CI)
• R(+)-Verapamil monohydrochloride
• (+)-[3-cyano-3-(3,4-diMethoxyphenyl)hex-6-yl](5,6-
• (αR)-α-[3-[[2-(3,4-DiMethoxyphenyl)ethyl]MethylaMino]propyl]-3,4-diMethoxy-α-(1-Methylethyl)-benzeneacetonitrile Hydrochloride
• R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE
• Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (alphaR)-
• R(+)-Verapamil monohydrochloride hydrate

(R)-Verapamil (hydrochloride)

CAS: 38176-02-2

(R)-Verapamil (hydrochloride)

Purity: 98%

Molecular weight: 491.06g/mol

Ref: 54-OR1034236

R-Verapamil HCl

CAS: 38176-02-2

Formula: C₂₇H₃₈N₂O₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 454.61 36.46

Ref: 4Z-V-046

R-(+)-Verapamil monohydrochloride hydrate

CAS: 38176-02-2

Formula: C₂₇H₄₁ClN₂O₅

Molecular weight: 509.08

Ref: 7W-GP6309

(R)-(+)-Verapamil Hydrochloride

Controlled Product

CAS: 38176-02-2

Applications (R)-(+)-Verapamil Hydrochloride and both of its isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Peroutka, S., et al.: J. Ann. Neurol, 23, 500 (1988); Eliason, J.F., et al.: Int. J. Cancer, 46, 113 (1990);

Formula: C₂₇H₃₈N₂O₄·ClH

Color and Shape: Neat

Molecular weight: 491.06

Ref: TR-V124990

(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride

CAS: 38176-02-2

(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride (ZD4054) is a drug that has been shown to be sensitive to the efflux pump in Escherichia coli. It is also able to inhibit multidrug resistance in nematodes and cross-resistance in humans. ZD4054 inhibits multidrug resistance by inhibiting the efflux of drugs from cells. This prevents the development of resistance to antibiotics and other drugs. The mechanism of action for this drug is unknown, but it may affect chloride channels that are found on the cell membrane. ZD4054 has also been shown to be effective against C.elegans and Drosophila melanogaster, two species commonly used for research purposes.

Formula: C₂₇H₃₉ClN₂O₄

Purity: Min. 95%

Molecular weight: 491.06 g/mol

Ref: 3D-ID28684

(R)-Verapamil hydrochloride

CAS: 38176-02-2

(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.

Formula: C₂₇H₃₉ClN₂O₄

Color and Shape: Solid

Molecular weight: 491.06

Ref: TM-T12646