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CAS 38194-50-2

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Sulindac

Description:
Sulindac is a non-steroidal anti-inflammatory drug (NSAID) primarily used for its analgesic and anti-inflammatory properties. It is classified as a sulfinyl derivative of indene and is known for its ability to inhibit cyclooxygenase (COX) enzymes, which play a crucial role in the synthesis of prostaglandins involved in inflammation and pain. Sulindac is typically administered in its prodrug form, which is metabolized in the body to its active sulfide form. This compound exhibits a relatively low solubility in water but is more soluble in organic solvents. It is often prescribed for conditions such as arthritis, bursitis, and other inflammatory disorders. Additionally, Sulindac has been studied for its potential chemopreventive effects in certain types of cancer. Common side effects may include gastrointestinal discomfort, and it is important to monitor for potential cardiovascular risks associated with long-term use. As with all medications, it should be used under the guidance of a healthcare professional, considering individual patient factors and potential drug interactions.
Formula:C20H17FO3S
InChI:InChI=1/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChI key:InChIKey=MLKXDPUZXIRXEP-MFOYZWKCNA-N
SMILES:C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(S(C)=O)C=C3
Synonyms:
  • (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
  • (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
  • (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
  • 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-
  • 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)-
  • 5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
  • Aflodac
  • Algocetil
  • Arthrocine
  • Artribid
  • See more synonyms
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