CAS 38213-69-3

Bis(maltolato)oxovanadium

Description:

Bis(maltolato)oxovanadium, with the CAS number 38213-69-3, is a coordination compound that features vanadium in its +4 oxidation state, coordinated by two maltolato ligands. Maltolato is derived from maltol, a compound known for its sweet aroma and flavor, and it acts as a bidentate ligand, coordinating through both the hydroxyl and carbonyl groups. This compound is notable for its potential biological activity, particularly in the context of diabetes management, as it has been studied for its insulin-mimetic properties. The vanadium center contributes to its reactivity and biological interactions. In terms of solubility, bis(maltolato)oxovanadium is typically soluble in polar solvents, which enhances its bioavailability. The compound's structure allows for interesting electronic properties, making it a subject of research in medicinal chemistry and materials science. Overall, bis(maltolato)oxovanadium exemplifies the intersection of inorganic chemistry and pharmacology, showcasing how metal complexes can be designed for specific therapeutic applications.

Formula: C₁₂H₁₀O₇V

InChI: InChI=1/2C6H6O3.O.V/c2*1-4-6(8)5(7)2-3-9-4;;/h2*2-3,8H,1H3;;/q;;;+2/p-2/r2C6H6O3.OV/c2*1-4-6(8)5(7)2-3-9-4;1-2/h2*2-3,8H,1H3;/q;;+2/p-2

InChI key: InChIKey=XUOLEICXAPEOSI-UHFFFAOYSA-L

SMILES: O=[V+2]12([O-]C=3C(=O1)C=COC3C)[O-]C=4C(=O2)C=COC4C

Synonyms:

• (SP-5-31)-Bis[3-(hydroxy-κO)-2-methyl-4H-pyran-4-onato-κO⁴]oxovanadium
• 4H-Pyran-4-one, 3-hydroxy-2-methyl-, vanadium complex
• Bis(Maltolato) oxo vanadium
• Bis(Maltolato)Oxovanadium(Iv)
• Bis(maltolato)oxovanadium
• Vanadium, bis(3-hydroxy-2-methyl-4H-pyran-4-onato-O³,O⁴)oxo-, (SP-5-31)-
• Vanadium, bis[3-(hydroxy-κO)-2-methyl-4H-pyran-4-onato-κO⁴]oxo-, (SP-5-31)-
• Vanadium, bis(3-hydroxy-2-methyl-4H-pyran-4-onato-O3,O4)oxo-, (SP-5-31)-
• (SP-5-31)-Bis[3-(hydroxy-κO)-2-methyl-4H-pyran-4-onato-κO4]oxovanadium
• Vanadium, bis[3-(hydroxy-κO)-2-methyl-4H-pyran-4-onato-κO4]oxo-, (SP-5-31)-
• BMOV

Bis(Maltolato)Oxovanadium(IV)

CAS: 38213-69-3

Bis(Maltolato)Oxovanadium(IV)

Purity: 98%

Molecular weight: 317.15g/mol

Ref: 54-IN12059

Bis(maltolato)oxovanadium(IV)

CAS: 38213-69-3

Bis(maltolato)oxovanadium(IV)

Purity: ≥98%

Molecular weight: 317.15g/mol

Ref: 54-BUP15475

Bis(maltolato)oxovanadium(IV)

CAS: 38213-69-3

BMOV: oral pan-PTP inhibitor, mimics insulin, anti-diabetic, improves heart function in diabetes, IC50s: 126-201 nM.

Formula: C₁₂H₁₀O₇V

Purity: 99.65% - 99.918%

Color and Shape: Solid

Molecular weight: 317.15

Ref: TM-T22276

Bis(maltolato)oxovanadium(IV)

Controlled Product

CAS: 38213-69-3

Applications It is a potent insulin mimic. Results showed that BMOV significantly decreased plasma glucose levels in diabetic rats at all given doses, and restored hyperglycemic values to normal value. BMOV has a promising outlook as an oral glucose-lowering drug.
References Cantley, L., et al.: J. Biol. Chem., 252, 7421 (1977), Shechter, Y., et al.: Diabetes, 39, 1 (1990), Cohen, N., et al.: J. Clin. Invest., 95, 2501 (1995), Reul, B., et al.: Br. J. Pharmacol., 126, 467 (1999), Yuen, V., et al.: Diabetes Res. Clin. Pract., 43, 9 (1999),

Formula: C₁₂H₁₀O₇V

Color and Shape: Neat

Molecular weight: 317.15

Ref: TR-B478500

Bis(maltolato)oxovanadium(IV)

CAS: 38213-69-3

Bis(maltolato)oxovanadium(IV) is a vanadium compound that has an insulin-like effect on blood glucose levels. It binds to the IL-2 receptor, which is an essential protein in the immune system. The binding of Bis(maltolato)oxovanadium(IV) to IL-2 receptor increases the production of IL-2 and activates insulin-sensitive K+ channels, resulting in increased uptake of glucose from the blood. This leads to decreased serum glucose levels and improved glycemic control. Although not fully understood, it is thought that this anti-diabetic drug may act through its interaction with the IL-2 receptor to regulate insulin sensitivity and glucose transport. In addition, Bis(maltolato)oxovanadium(IV) has been shown to have a protective effect on myocardial infarction (heart attack), as well as protecting against iron deficiency by increasing iron homeostasis.

Formula: C₁₂H₁₀O₇V

Purity: Min. 95%

Color and Shape: Brown Powder

Molecular weight: 317.15 g/mol

Ref: 3D-FB18735