CAS 38243-03-7

R-Ginsenoside Rg3

Description:

R-Ginsenoside Rg3 is a natural compound derived from ginseng, specifically a type of ginsenoside, which are steroidal saponins known for their various pharmacological properties. It is characterized by its molecular formula, which reflects its complex structure, typically featuring a steroid backbone with sugar moieties. Rg3 exists in two stereoisomeric forms, with the R form being biologically active. This compound is recognized for its potential health benefits, including anti-cancer, anti-inflammatory, and neuroprotective effects. Rg3 has been studied for its ability to modulate various biological pathways, including apoptosis and cell proliferation, making it of interest in both traditional medicine and modern pharmacology. Additionally, it is often explored in the context of enhancing immune function and improving overall vitality. Its solubility and stability can vary based on the formulation and conditions, which are important considerations for its application in dietary supplements and therapeutic agents. Overall, R-Ginsenoside Rg3 represents a significant area of research in natural products chemistry and medicinal applications.

Formula: C₄₂H₇₂O₁₃

InChI: InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,39-,40+,41+,42+/m0/s1

InChI key: InChIKey=RWXIFXNRCLMQCD-CZIWJLDFSA-N

SMILES: C[C@]12[C@@]3(C)[C@@]([C@@]([C@](CCC=C(C)C)(C)O)(CC3)[H])([C@H](O)C[C@@]1([C@]4(C)[C@@](CC2)(C(C)(C)[C@@H](O[C@H]5[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@H](O)[C@H](O)[C@@H](CO)O5)CC4)[H])[H])[H]

Synonyms:

• (20S)-Propanaxadiol
• (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(10R,12S,13R,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxa
• (3Beta,12Beta)-12,20-Dihydroxydammar-24-En-3-Yl 2-O-Beta-D-Glucopyranosyl-Beta-D-Glucopyranoside
• (3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-glucopyranoside
• (3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→2)-β-<smallcap>D</span>-glucopyranoside
• (5xi,8xi,9xi,12alpha,14beta,20R)-12,20-dihydroxylanost-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
• (8xi,9xi,12alpha,14beta,17alpha)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,14-tetramethylgonan-3-yl 2-O-[3-deoxy-3-(hydroxymethyl)-beta-D-glucopyranosyl]-beta-D-glucopyranoside
• 20(R)-Ginsenoside Rg₃
• 20(R)-Propanaxadiol
• 20(S)-Ginsenoside-Rg3
• 20R-Ginsenoside Rg3
• Beta-D-Glucopyranoside,(3-Beta,12-Beta)-12,20-Dihydroxydammar-24-En-3-Yl2-O-B
• Dammar-24-Ene-12-Beta,20-Diol,3-Beta-((2-O-Beta-D-Glucopyranosyl-Beta-D-Gluc
• Dammar-24-ene-12β,20-diol, 3β-[(2-O-β-D-
• Eta-D-Glucopyranosyl-
• Ginsenoside rg3(R)
• Opyransoyl)Oxy)-
• R-Ginsenoside Rg₃
• beta-D-Glucopyranoside,(3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,12β,20R)-12,20-dihydroxydammar-24-en-3-yl 2-O-β-<smallcap>D</span>-glucopyranosyl-
• (3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
• 20(R)-Ginsenoside Rg3
• (3β,12β,20R)-12,20-Dihydroxydammar-24-en-3-yl O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside

20(R)-Propanaxadiol

CAS: 38243-03-7

Ref: 7W-GC5327

(20R)-Ginsenoside Rg3

CAS: 38243-03-7

(20R)-Ginsenoside Rg3

Purity: ≥95%

Molecular weight: 785.01g/mol

Ref: 54-BUP00028

20(R)-Ginsenoside Rg3

CAS: 38243-03-7

20(R)-Ginsenoside Rg3 has shown multiple pharmacological activities and been considered as one of the most promising approaches for fatigue treatment, however, 20(R)-Ginsenoside Rg3 has a low bioavailability after oral administration in human, so, 20(R)-Rg3 can be by intranasal administration, the mechanism was related to the increase of the storage of hepatic glycogen, and the decrease of the accumulation of metabolite such as lactic acid and serum urea nitrogen.

Formula: C₄₂H₇₂O₁₃

Purity: 95%~99%

Color and Shape: White powder

Molecular weight: 785.025

Ref: BP-BP0040

20(R)-Ginsenoside Rg3

CAS: 38243-03-7

Formula: C₄₂H₇₂O₁₃

Purity: >97.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 785.03

Ref: 3B-G0536

(20R)-Ginsenoside Rg3

CAS: 38243-03-7

(20R)-Ginsenoside Rg3 (20(R)-Propanaxadiol) is a compound with anti-aging and antifatigue activities.

Formula: C₄₂H₇₂O₁₃

Purity: 97.03% - 99.67%

Color and Shape: Solid

Molecular weight: 785.01

Ref: TM-T3812

20(R)-Ginsenoside Rg3

Controlled Product

CAS: 38243-03-7

Applications 20(R)-Ginsenoside Rg3 causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated. Elicits a significant inhibition of in vitro cell adhesion and invasion of U87 cells. in vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase isoforms and in vivo inhibition of tumor angiogenesis of lung cancer.
References Liu, Y., et al.: Chengdu Yixueyuan Xuebao, 9, 4 (2014); Liu, Y., et al.: Linchuang Junyi Zazhi, 42, 1138 (2014), Kim, D., et al.: Toxicol. Lett., 259, 1 92016); Geng, L., et al.: Zhonghua Zhongyiyao Zazhi, 29, 601 (2014)

Formula: C₄₂H₇₂O₁₃

Color and Shape: Neat

Molecular weight: 785.01

Ref: TR-G387625

(20R)-Ginsenoside Rg3

CAS: 38243-03-7

(20R)-Ginsenoside Rg3 is a triterpenoid saponin, which is a bioactive compound isolated from the root of Panax ginseng. This product is an integral part of traditional medicine and is now being extensively studied in modern pharmacological research. As a ginsenoside, Rg3 exerts its effects primarily by modulating cellular pathways, inhibiting angiogenesis, and inducing apoptosis in cancer cells.

Formula: C₄₂H₇₂O₁₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 785.01 g/mol

Ref: 3D-OG15964

20(R)-Ginsenoside Rg3-d6

Controlled Product

CAS: 38243-03-7

Formula: C₄₂D₆H₆₆O₁₃

Color and Shape: Neat

Molecular weight: 791.05

Ref: TR-G410288

20(R)-Propanaxadiol

CAS: 38243-03-7

Formula: C₄₂H₇₂O₁₃

Color and Shape: Solid

Molecular weight: 785.0133

Ref: IN-DA00BXSG