CAS 38363-41-6

(2R)-1-(2-Cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol

Description:

The chemical substance known as (2R)-1-(2-Cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol, with the CAS number 38363-41-6, is a selective beta-adrenergic antagonist. It is characterized by its chiral center, which contributes to its specific biological activity. The compound features a cyclopentylphenyl moiety, which enhances its lipophilicity, allowing for better membrane permeability. The presence of a tert-butylamino group is significant for its pharmacological properties, as it influences receptor binding and selectivity. This substance is typically studied for its potential therapeutic applications, particularly in cardiovascular diseases, due to its ability to modulate heart rate and contractility. Its solubility and stability in various solvents can vary, impacting its formulation and delivery in pharmaceutical contexts. Overall, this compound exemplifies the complexity of drug design, where structural modifications can lead to significant differences in biological activity and therapeutic efficacy.

Formula: C₁₈H₂₉NO₂

InChI: InChI=1S/C18H29NO2/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3/t15-/m1/s1

InChI key: InChIKey=KQXKVJAGOJTNJS-OAHLLOKOSA-N

SMILES: O(C[C@@H](CNC(C)(C)C)O)C1=C(C=CC=C1)C2CCCC2

Synonyms:

• (+)-(R)-Penbutolol
• (+)-Isopenbutolol
• (+)-Penbutolol
• (2R)-1-(2-Cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol
• 2-Propanol, 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (R)-
• 2-propanol, 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (2R)-
• d-Penbutolol

(+)-Penbutolol

CAS: 38363-41-6

(+)-Penbutolol is an antagonist of β-adrenoceptor(IC50 of 0.74 μM). (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action.

Formula: C₁₈H₂₉NO₂

Color and Shape: Solid

Molecular weight: 291.43

Ref: TM-T13465

(+)-Penbutolol

CAS: 38363-41-6

Penbutolol is a beta-adrenergic blocking agent that is used to treat high blood pressure and some types of heart disease. It has been shown to inhibit the binding of a linker, expressed as (+)-penbutolol, to the beta-adrenergic receptor in cardiac muscle cells. Penbutolol prevents an increase in intracellular calcium by acting as an antagonist at the alpha-1 adrenergic receptor, which is responsible for the release of norepinephrine from sympathetic nerve terminals. This drug also decreases systolic and diastolic blood pressure, but does not have any effect on heart rate. Penbutolol has been shown to be effective in treating hypertension and angina pectoris with no serious side effects when taken at low doses.

Formula: C₁₈H₂₉NO₂

Purity: Min. 95%

Molecular weight: 291.4 g/mol

Ref: 3D-NBA36341