CAS 38390-45-3
:Anhydrovinblastine
Description:
Anhydrovinblastine is a chemical compound that belongs to the class of alkaloids, specifically derived from the periwinkle plant, Catharanthus roseus. It is a derivative of vinblastine, a well-known chemotherapeutic agent used in cancer treatment. Anhydrovinblastine is characterized by its complex structure, which includes a tetracyclic indole alkaloid framework. This compound exhibits significant biological activity, particularly in its ability to inhibit cell division by disrupting microtubule formation during mitosis, making it a subject of interest in cancer research. Its mechanism of action is primarily through binding to tubulin, thereby preventing the polymerization necessary for microtubule assembly. Anhydrovinblastine is typically studied for its potential therapeutic applications, as well as its pharmacological properties, including cytotoxicity against various cancer cell lines. However, due to its potent effects, careful handling and consideration of dosage are essential in any experimental or clinical context. As with many alkaloids, its use is accompanied by a profile of side effects and toxicity that must be managed in therapeutic settings.
Formula:C46H56N4O8
InChI:InChI=1/C46H56N4O8/c1-8-28-21-29-24-45(41(52)56-6,37-31(15-19-49(25-28)26-29)30-13-10-11-14-34(30)47-37)33-22-32-35(23-36(33)55-5)48(4)39-44(32)17-20-50-18-12-16-43(9-2,38(44)50)40(58-27(3)51)46(39,54)42(53)57-7/h10-14,16,21-23,29,38-40,47,54H,8-9,15,17-20,24-26H2,1-7H3/t29-,38+,39-,40-,43-,44-,45+,46+/m1/s1
InChI key:InChIKey=FFRFGVHNKJYNOV-ZCIMLLHDSA-N
SMILES:C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CC[N@@]9C[C@](C6)(C=C(CC)C9)[H])[H])CCN3CC=C2)[H]
Synonyms:- 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
- 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
- 3',4'-Dehydroisoleurosine
- 3',4'-Dehydrovinblastine
- 3',4'-Didehydro-4'-deoxuvincaleukoblastine
- 3',4'-Didehydroisoleurosine
- 3',4'-Didehydrovinblastine
- 3′,4′-Anhydrovinblastine
- 3′,4′-Dehydroisoleurosine
- 3′,4′-Dehydrovinblastine
- 3′,4′-Didehydro-4′-deoxyvincaleukoblastine
- 3′,4′-Didehydroisoleurosine
- 3′,4′-Didehydrovinblastine
- Anhydrovinblastine
- Anhydrovincaleukoblastine
- F 81097
- Vincaleukoblastine, 3',4'-didehydro-4'-deoxy-
- Vincaleukoblastine, 3′,4′-didehydro-4′-deoxy-
- methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(7S,9S)-5-ethyl-9-(methoxycarbonyl)-1,4,7,8,9,10-hexahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
- methyl (2beta,3beta,4beta,5alpha,19alpha)-4-(acetyloxy)-15-[(7R,9S)-5-ethyl-9-(methoxycarbonyl)-1,4,7,8,9,10-hexahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
- C11641
- 3,4-ANHYDROVINBLASTINE,95%
- 3',4'-Anhydrovinblastine USP/EP/BP
- ANHYDROVINBLASTIN
- Vinorelbine EP Impurity J/Anhydro Vinblastine Disulfate
- 3',4'-Didehydro-4'-deoxyvincaleukoblastine
- DISCONTINUED. Please see A659750.
- 3',4'-anhydrovinblastine
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 4 products.
Anhydrovinblastine
CAS:3', 4'-Anhydrovinblastine (3',4'-Anhydrovinblastine) is an antineoplastic agent.Formula:C46H56N4O8Purity:98%Color and Shape:White Crystal PowerMolecular weight:792.96Anhydro Vinblastine Disulfate Salt
CAS:<p>Stability Hygroscopic, Temperature Sensitive<br>Applications Anhydrovinblastine showed significant cytotoxic potential against a panel of human cancer cell lines and significant activity against the human H460 non-small cell lung carcinoma tumor xenograph in mice.<br>References Koiso, Y., et al.: J. Antibiot., 51, 418 (1998), Olver, I., et al.: Eur. J. Cancer, 43, 1829 (2007), Shao, Y., et al.: Bioorg. Med. Chem., 15, 5061 (2007).<br></p>Formula:C46H56N4O8·2H2SO4Color and Shape:NeatMolecular weight:989.11
