CAS 38398-32-2
:Ganaxolone
Description:
Ganaxolone is a synthetic neuroactive steroid and a derivative of allopregnanolone, primarily known for its anticonvulsant properties. It acts as a positive allosteric modulator of the GABA-A receptor, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the central nervous system. This mechanism makes it a candidate for treating various neurological disorders, including epilepsy and anxiety. Ganaxolone is characterized by its lipophilic nature, which facilitates its ability to cross the blood-brain barrier. The compound has a relatively low solubility in water but is soluble in organic solvents, which is typical for many steroid derivatives. Its pharmacokinetic profile includes a moderate half-life, allowing for sustained therapeutic effects. Clinical studies have indicated that ganaxolone may have a favorable safety profile, with side effects generally being mild to moderate. Overall, ganaxolone represents a promising therapeutic option in the realm of neurology, particularly for patients who may not respond well to traditional anticonvulsant medications.
Formula:C22H36O2
InChI:InChI=1S/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17+,18-,19-,20+,21-,22+/m0/s1
InChI key:InChIKey=PGTVWKLGGCQMBR-FLBATMFCSA-N
SMILES:C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(CC[C@]1(C[C@](C)(O)CC2)[H])[H])[H]
Synonyms:- (3Alpha,5Alpha)-3-Hydroxy-3-Methylpregnan-20-One
- (3Alpha,5Alpha,8Xi,9Xi,14Xi)-3-Hydroxy-3-Methylpregnan-20-One
- (3α,5α)-3-Hydroxy-3-methylpregnan-20-one
- 3α-Hydroxy-3β-methyl-5α-pregnan-20-one
- 5α-Pregnan-20-one, 3α-hydroxy-3-methyl-
- Ccd-1042
- Ganaxolone
- Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-
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Found 5 products.
Ganaxolone
CAS:Formula:C22H36O2Purity:≥ 97%Color and Shape:White to off-white crystalline powderMolecular weight:332.52Ganaxolone
CAS:Controlled Product<p>Ganaxolone is a therapeutic agent that is used to treat epilepsy. It binds to the GABA receptor and blocks the action of GABA, which is an inhibitory neurotransmitter. This binding prevents GABA from binding to the receptor and reduces neuronal excitability in the brain. The pharmacological effects of ganaxolone are irreversible because they are due to the formation of covalent bonds with basic proteins in neurons. Ganaxolone has been shown to increase locomotor activity in rats, but not affect performance on a rotarod test or basic sensory and motor abilities. The effect of ganaxolone on human macrophages has been demonstrated using an analytical method that measures the release of reactive oxygen species (ROS) from these cells. The long-term efficacy of ganaxolone has been assessed by evaluating its ability to prevent seizures in patients with refractory epilepsy who have not responded adequately to other treatments.</p>Formula:C22H36O2Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:332.52 g/mol
