CAS 3862-25-7
:7α-Hydroxy-4-cholesten-3-one
Description:
7α-Hydroxy-4-cholesten-3-one, with the CAS number 3862-25-7, is a steroid compound that plays a significant role in cholesterol metabolism and is a key intermediate in the biosynthesis of bile acids. This compound features a hydroxyl group at the 7α position of the cholestene backbone, which contributes to its biological activity. It is typically found in various biological systems, including human tissues, where it is involved in the regulation of cholesterol levels and may influence lipid metabolism. The presence of the hydroxyl group enhances its solubility in biological fluids, facilitating its interaction with enzymes and receptors. Additionally, 7α-Hydroxy-4-cholesten-3-one is known to be a ligand for liver X receptors (LXRs), which are nuclear receptors that regulate genes involved in lipid homeostasis. Its structural characteristics, including the steroid framework and functional groups, are crucial for its biological functions and potential therapeutic applications in managing cholesterol-related disorders.
Formula:C27H44O2
InChI:InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1
InChI key:InChIKey=IOIZWEJGGCZDOL-RQDYSCIWSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(C[C@H]3O)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]
Synonyms:- (7Alpha,8Xi)-7-Hydroxycholest-4-En-3-One
- (7α)-7-Hydroxycholest-4-en-3-one
- 7α-Hydroxy-4-cholesten-3-one
- 7α-Hydroxycholest-4-en-3-one
- Cholest-4-En-3-One, 7-Hydroxy-, (7Alpha,8Xi)-
- Cholest-4-en-3-one, 7-hydroxy-, (7alpha)-
- Cholest-4-en-3-one, 7-hydroxy-, (7α)-
- Cholest-4-en-3-one, 7α-hydroxy-
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Found 11 products.
(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
CAS:Formula:C27H44O2Purity:%Color and Shape:SolidMolecular weight:400.63717α-Hydroxy-4-cholesten-3-one-d7 (contains 2% d0)
CAS:Controlled Product<p>Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),<br></p>Formula:C27H37D7O2Color and Shape:NeatMolecular weight:407.687α-Hydroxy-4-cholesten-3-one-d7
CAS:Controlled Product<p>Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969),<br></p>Formula:C27H37D7O2Color and Shape:White To Off-WhiteMolecular weight:407.687α-Hydroxy-4-cholesten-3-one
CAS:<p>Applications 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),<br></p>Formula:C27H44O2Color and Shape:NeatMolecular weight:400.647α-Hydroxy-4-cholesten-3-one
CAS:Controlled Product<p>Intermediate in bile acids biosynthesis</p>Formula:C27H44O2Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:400.64 g/mol7-Hydroxy-4-cholesten-3-one-D7
CAS:Controlled Product<p>7-Hydroxy-4-cholesten-3-one-D7 (7OHCD7) is a metabolite of the bile acid, cholic acid. It is generated by the action of cholesterol 7α hydroxylase on cholesterol in the liver. It is excreted in bile, which is then absorbed back into the body from the gut and used for energy metabolism. 7OHCD7 has been shown to be an inhibitor of histone deacetylases, which are enzymes that regulate gene transcription. This inhibition leads to increased transcriptional regulation and reduced inflammatory responses in bowel disease models. 7OHCD7 has also been shown to increase cholesterol levels and reduce inflammation in humans with metabolic syndrome.</p>Formula:C27H44O2Purity:Min. 95%Molecular weight:400.64 g/mol7α-Hydroxy-4-cholesten-3-one
CAS:7α-Hydroxy-4-cholesten-3-one is a PXR agonist that can be used to study diseases associated with defects in bile acid biosynthesis.Formula:C27H44O2Purity:99.14%Color and Shape:White SolidMolecular weight:400.64
![(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,1…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00C9GN.jpg&w=3840&q=75)
