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CAS 3863-59-0

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Hydrocortisone phosphate

Description:
Hydrocortisone phosphate, with the CAS number 3863-59-0, is a synthetic derivative of hydrocortisone, which is a naturally occurring steroid hormone produced by the adrenal glands. This compound is characterized by its phosphate ester form, which enhances its solubility and bioavailability compared to its parent compound. Hydrocortisone phosphate exhibits anti-inflammatory and immunosuppressive properties, making it useful in various medical applications, particularly in treating conditions such as allergies, skin disorders, and autoimmune diseases. It is often administered topically or via injection, depending on the therapeutic need. The compound is typically stable under standard conditions but may be sensitive to light and moisture, necessitating proper storage. Its mechanism of action involves binding to glucocorticoid receptors, leading to the modulation of gene expression and subsequent reduction of inflammation. As with other corticosteroids, careful consideration of dosage and duration of use is essential to minimize potential side effects, including adrenal suppression and metabolic changes.
Formula:C21H31O8P
InChI:InChI=1S/C21H31O8P/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19/h9,14-16,18,23,25H,3-8,10-11H2,1-2H3,(H2,26,27,28)/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key:InChIKey=BGSOJVFOEQLVMH-VWUMJDOOSA-N
SMILES:C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@]2(C(COP(=O)(O)O)=O)O)[H]
Synonyms:
  • (11Beta)-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl Dihydrogen Phosphate
  • (11β)-11,17-Dihydroxy-21-(phosphonooxy)pregn-4-ene-3,20-dione
  • (8Xi,9Xi,10Xi,13Xi,14Xi)-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl Dihydrogen Phosphate
  • 11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Yl Dihydrogen Phosphate
  • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate)
  • 21-Hydrocortisonephosphoric acid
  • Corphos
  • Corticosterone, 17-hydroxy-, 21-phosphate
  • Cortisol 21-monophosphate
  • Cortisol 21-phosphate
  • See more synonyms
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