CAS 38647-10-8

Tripdiolide

Description:

Tripdiolide is a natural compound classified as a sesquiterpene lactone, primarily derived from the plant species *Tripterygium wilfordii*, commonly known as Thunder God Vine. This compound is notable for its complex molecular structure, which includes multiple rings and functional groups that contribute to its biological activity. Tripdiolide exhibits anti-inflammatory and immunosuppressive properties, making it of interest in pharmacological research, particularly for conditions such as autoimmune diseases and organ transplantation. Its mechanism of action involves the modulation of various signaling pathways, including the inhibition of nuclear factor kappa B (NF-κB) activation. Additionally, Tripdiolide has been studied for its potential anticancer effects, as it may induce apoptosis in certain cancer cell lines. However, its use is tempered by potential toxicity and side effects, necessitating careful consideration in therapeutic applications. Overall, Tripdiolide represents a significant area of study in natural product chemistry and medicinal research, highlighting the importance of plant-derived compounds in drug discovery.

Formula: C₂₀H₂₄O₇

InChI: InChI=1/C20H24O7/c1-7(2)18-13(26-18)14-20(27-14)17(3)5-10(21)12-8(6-24-15(12)22)9(17)4-11-19(20,25-11)16(18)23/h7,9-11,13-14,16,21,23H,4-6H2,1-3H3/t9-,10-,11-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChI key: InChIKey=PUJWFVBVNFXCHZ-SQEQANQOSA-N

SMILES: C[C@@]12[C@@]34[C@@]5([C@@](O5)(C[C@]1(C6=C([C@@H](O)C2)C(=O)OC6)[H])[H])[C@H](O)[C@]7([C@H](C)C)[C@]([C@@]3(O4)[H])(O7)[H]

Synonyms:

• (2beta)-2-Hydroxytriptolide
• (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS,10S)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6,10-dihydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
• (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS,10S)-6,10-dihydroxy-8b-methyl-6a-(propan-2-yl)-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydrotrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1(3H)-one
• Nsc 163063
• Tripdiolid
• Triptodiolide
• Triptolide, 2-hydroxy-, (2-beta)-
• Triptolide, 2-hydroxy-, (2beta)- (9CI)
• Triptolide, 2-hydroxy-, (2β)-
• Trisoxireno(4b,5:6,7:8a,9)phenanthro(1,2-c)furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6,10-dihydroxy-8b-methyl-6a-(1- methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS,10S)-
• Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6,10-dihydroxy-8b-methyl-6a-(1-methylethyl)-, [3bS-(3bα,4aα,5aR*,6β,6aβ,7aβ,7bα,8aR*,8bβ,10β)]-
• Tripdiolide
• 2BETA-HYDROXY-TRIPTOLIDE
• (2-beta)-triptolid
• 8b,9,10-decahydro-6,10-dihydroxy-8b-methyl-6a-(1-methylethyl)-,(3bs,4as,5as,6
• nsc163063
• 7as,7bs,8as,8bs,10s)-6ar
• trisoxireno(4b,5:6,7:8a,9)phenanthro(1,2-c)furan-1(3h)-one,3b,4,4a,6,6a,7a,7b,
• TRIPDIOLIDE(P)
• Tripdiolide USP/EP/BP
• Tripdiolide 38647-10-8

Tripdiolide

CAS: 38647-10-8

Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.

Formula: C₂₀H₂₄O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 376.405

Ref: TM-T4S1057

Triptodiolide

CAS: 38647-10-8

Formula: C₂₀H₂₄O₇

Molecular weight: 376.40

Ref: 7W-GP7405

Tripdiolide

CAS: 38647-10-8

Formula: C₂₀H₂₄O₇

Molecular weight: 376.41

Ref: 4Z-T-149010

Tripdiolide

CAS: 38647-10-8

Tripdiolide is a bioactive diterpenoid, which is derived from the Chinese medicinal plant Tripterygium wilfordii, commonly known as Thunder God Vine. This compound exerts its effects through a complex mode of action, primarily involving the inhibition of nuclear factor kappa B (NF-kB) signaling pathways and the induction of apoptosis. Recent studies have also suggested its role in modulating the immune response by targeting specific cytokines and signaling pathways.

Purity: Min. 95%

Color and Shape: Powder

Ref: 3D-FT137875