CAS 3868-31-3

8-Hydroxyguanosine

Description:

8-Hydroxyguanosine is a modified nucleoside that arises from the oxidative damage of guanosine, a key component of RNA. Its chemical structure features a hydroxyl group at the 8-position of the guanine base, which contributes to its unique properties. This modification can occur due to oxidative stress, making 8-hydroxyguanosine a marker for oxidative damage in biological systems. It is soluble in water and exhibits a polar nature due to the presence of hydroxyl groups. The substance plays a significant role in various biological processes, including cellular signaling and the regulation of gene expression. Additionally, it has been studied for its potential implications in diseases related to oxidative stress, such as cancer and neurodegenerative disorders. Analytical techniques like high-performance liquid chromatography (HPLC) and mass spectrometry are commonly employed to detect and quantify 8-hydroxyguanosine in biological samples. Overall, its presence and levels can provide insights into cellular health and the oxidative state of tissues.

Formula: C₁₀H₁₃N₅O₆

InChI: InChI=1S/C10H13N5O6/c11-9-13-6-3(7(19)14-9)12-10(20)15(6)8-5(18)4(17)2(1-16)21-8/h2,4-5,8,16-18H,1H2,(H,12,20)(H3,11,13,14,19)/t2-,4-,5-,8-/m1/s1

InChI key: InChIKey=FPGSEBKFEJEOSA-UMMCILCDSA-N

SMILES: O=C1N(C2=C(N1)C(=O)N=C(N)N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

Synonyms:

• 2-Amino-9-beta-D-ribofuranosylpurine-6,8(1H,9H)-dione
• 2-amino-9-pentofuranosyl-7,9-dihydro-3H-purine-6,8-dione
• 7,8-Dihydro-8-oxoguanosine
• 8-Oxo-2'-deoxyguanosine
• 8-Oxo-7,8-dihydroguanosine
• 8-Oxoguanosine
• Ccris 8242
• Chembridge 5144558
• Guanosine, 7,8-dihydro-8-oxo-
• Nqz-013
• Nsc 90393
• Purine-6,8(1H,9H)-dione, 2-amino-9-beta-D-ribofuranosyl-
• Purine-6,8(1H,9H)-dione, 2-amino-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 8-Hydroxyguanosine

8-Hydroxyguanosine

CAS: 3868-31-3

Formula: C₁₀H₁₃N₅O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 299.2401

Ref: IN-DA00BYFT

8-Oxoguanosine

CAS: 3868-31-3

Ref: 7W-GN3868

8-Hydroxyguanosine

CAS: 3868-31-3

8-Hydroxyguanosine

Purity: ≥95%

Molecular weight: 299.24g/mol

Ref: 54-BUP11476

8-Hydroxyguanosine

CAS: 3868-31-3

Formula: C₁₀H₁₃N₅O₆

Purity: >90.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 299.24

Ref: 3B-O0661

8-Hydroxyguanosine

CAS: 3868-31-3

8-hydroxyguanosine (8-OHG) is a marker for measuring the rate of oxidative damage to nucleic acids and lipids.

Formula: C₁₀H₁₃N₅O₆

Purity: 96.67% - 99.67%

Color and Shape: Solid

Molecular weight: 299.24

Ref: TM-TQ0154

8-Hydroxy Guanosine

CAS: 3868-31-3

Formula: C₁₀H₁₃N₅O₆

Color and Shape: Off White Crystalline

Molecular weight: 299.24

Ref: TR-H942770

8-Hydroxy Guanosine-13C,15N2

CAS: 3868-31-3

Stability Hygroscopic
Applications Labelled 8-Hydroxy Guanosine (H942770). It is a representative metabolite derived by the oxidation of Guanosine (G) and is regarded as a marker of oxidative stress in the cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lin, T.-S. et al.: J. Med. Chem., 28, 1194 (1985), Risom, L., et al.: Mutat. Res., 592, 119 (2005), Knaapen, A., et al.: Mutagenesis, 21, 225 (2006),

Formula: C₉₁₃CH₁₃N₃₁₅N₂O₆

Color and Shape: Off White Solid

Molecular weight: 302.22

Ref: TR-H942772

8-Oxoguanosine

CAS: 3868-31-3

8-Oxoguanosine is an oxidative DNA lesion that has been shown to be a potential biomarker for the detection of cancer cells. 8-Oxoguanosine is produced by a number of pharmacological agents and reactive oxygen species, such as hydrogen peroxide and nitric oxide. It has been shown to bind to DNA duplexes, inhibiting their replication and repair, which may lead to cancer development. The electrochemical detector can detect 8-oxoguanosine at concentrations as low as 1 μM in biological samples.

Formula: C₁₀H₁₃N₅O₆

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 299.24 g/mol

Ref: 3D-NO05772