CAS 38748-32-2

Triptolide

Description:

Triptolide is a bioactive compound derived from the plant Tripterygium wilfordii, commonly known as Thunder God Vine. It is classified as a diterpenoid and is known for its potent anti-inflammatory and immunosuppressive properties. Triptolide has been studied for its potential therapeutic effects in various conditions, including autoimmune diseases and cancer. The compound exhibits a complex structure characterized by a fused ring system, which contributes to its biological activity. Triptolide functions by inhibiting several signaling pathways, including NF-κB and MAPK, leading to reduced expression of pro-inflammatory cytokines. Despite its promising therapeutic potential, triptolide also has a narrow therapeutic window and can exhibit cytotoxic effects, necessitating careful consideration in clinical applications. Its solubility is limited in water, which can pose challenges for formulation in pharmaceutical contexts. Ongoing research continues to explore its mechanisms of action, efficacy, and safety profile, aiming to harness its benefits while mitigating adverse effects.

Formula: C₂₀H₂₄O₆

InChI: InChI=1/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChI key: InChIKey=DFBIRQPKNDILPW-CIVMWXNOSA-N

SMILES: C[C@@]12[C@@]34[C@@]5([C@@](O5)(C[C@]1(C6=C(CC2)C(=O)OC6)[H])[H])[C@H](O)[C@]7([C@H](C)C)[C@]([C@@]3(O4)[H])(O7)[H]

Synonyms:

• (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
• (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-6-hydroxy-8b-methyl-6a-(propan-2-yl)-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydrotrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1(3H)-one
• NSC 163062
• Pg 490
• Triptergium glycosides
• Triptolid
• Triptolide 95%
• Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-
• [3bS-(3bα,4aα,5aR*,6β,6aβ,7aβ,7bα,8aR*,8bβ)]-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
• Triptolide
• PG490
• TRIPTOLIDE, TRIPTERYGIUM WILFORDII
• TRIPTONIDE(P)
• 8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-,(3bs,4as,5as,6r,6ar
• TRIPTOLIDE TLC
• TRIPTOLIDE95%
• ,7as,7bs,8as,8bs)-

Triptolide

CAS: 38748-32-2

Formula: C₂₀H₂₄O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 360.41

Ref: 3B-T2899

Triptolide

CAS: 38748-32-2

Formula: C₂₀H₂₄O₆

Purity: %

Color and Shape: Solid

Molecular weight: 360.4010

Ref: IN-DA0035UZ

Triptolide

CAS: 38748-32-2

Triptolide

Purity: ≥95%

Molecular weight: 360.4g/mol

Ref: 54-BUP07175

Triptolide

CAS: 38748-32-2

Formula: C₂₀H₂₄O₆

Color and Shape: White To Off-White Solid

Molecular weight: 360.41

Ref: 4Z-T-149002

Triptolide

CAS: 38748-32-2

Formula: C₂₀H₂₄O₆

Purity: 95%~99%

Molecular weight: 360.406

Ref: BP-BP1411

Triptolide

CAS: 38748-32-2

Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation.

Formula: C₂₀H₂₄O₆

Purity: 97.19% - 99.97%

Color and Shape: White To Off-White Solid

Molecular weight: 360.4

Ref: TM-T2179

Triptolide

CAS: 38748-32-2

Formula: C₂₀H₂₄O₆

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline solid

Molecular weight: 360.40

Ref: 7W-GP2934

Triptolide

CAS: 38748-32-2

Triptolide

Formula: C₂₁H₂₆O₆

Purity: By hplc: 99.25% (Typical Value in Batch COA)

Color and Shape: white crystals

Molecular weight: 374.43g/mol

Ref: 54-BIA8418

Triptolide

CAS: 38748-32-2

Lactone

Formula: C₂₀H₂₄O₆

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 360.41

Ref: 5G-89811

Triptolide

Controlled Product

CAS: 38748-32-2

Applications Triptolide is a diterpenoid triepoxide with immunosuppressant and antitumor properties.
References Hikim, S., et al.: J. Androl., 21, 431 (2000), Chang, W.-T., et al.: J. Biol. Chem., 276, 222 (2001), Kiviharju, T.M., et al.: Clin. Cancer Res., 8, 2666 (2002), Leuenroth, S.J., et al.: Chem. Biol., 12, 1259 (2005),

Formula: C₂₀H₂₄O₆

Color and Shape: White To Off-White

Molecular weight: 360.40

Ref: TR-T815600

Triptolide-d3 (major) (>90%)

Controlled Product

CAS: 38748-32-2

Applications Triptolide-d3 is labelled Triptolite (T815600), a diterpenoid triepoxide with immunosuppressant and antitumor properties.
References Hikim, S., et al.: J. Androl., 21, 431 (2000), Chang, W.-T., et al.: J. Biol. Chem., 276, 222 (2001), Kiviharju, T.M., et al.: Clin. Cancer Res., 8, 2666 (2002), Leuenroth, S.J., et al.: Chem. Biol., 12, 1259 (2005),

Formula: C₂₀H₂₁D₃O₆

Purity: >90%

Color and Shape: White To Light Yellow

Molecular weight: 363.42

Ref: TR-T815602

Triptolide

CAS: 38748-32-2

Inhibits RNAPII-mediated trasncription; immunosuppressant; anti-inflammatory

Formula: C₂₀H₂₄O₆

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 360.4 g/mol

Ref: 3D-FT28581

Triptolide ex. Tripterigium Wilfordii for cell culture, 98%

CAS: 38748-32-2

Formula: C₂₀H₂₄O₆

Molecular weight: 360.40

Ref: SR-35416

Triptolide

CAS: 38748-32-2

Molecular weight: 360.16

Ref: 10-F557653