CAS 38753-77-4

7α-(Thiomethyl)spironolactone

Description:

7α-(Thiomethyl)spironolactone is a synthetic compound that belongs to the class of steroidal compounds, specifically a derivative of spironolactone, which is a well-known diuretic and antihypertensive medication. This compound features a thiomethyl group at the 7α position, which modifies its pharmacological properties compared to its parent compound. It is characterized by its ability to interact with mineralocorticoid receptors, potentially influencing electrolyte balance and fluid retention. The presence of the thiomethyl group may enhance its lipophilicity and alter its metabolic pathways. As with many steroid derivatives, it may exhibit a range of biological activities, including anti-inflammatory and antifibrotic effects. The compound's structure allows for potential applications in research related to cardiovascular health, renal function, and hormonal regulation. However, detailed studies on its specific pharmacodynamics, toxicity, and therapeutic efficacy are essential for understanding its full potential and safety profile.

Formula: C₂₃H₃₂O₃S

InChI: InChI=1/C23H32O3S/c1-21-8-4-15(24)12-14(21)13-18(27-3)20-16(21)5-9-22(2)17(20)6-10-23(22)11-7-19(25)26-23/h12,16-18,20H,4-11,13H2,1-3H3/t16-,17-,18+,20+,21-,22-,23+/m0/s1

InChI key: InChIKey=FWRDLPQBEOKIRE-RJKHXGPOSA-N

SMILES: C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3

Synonyms:

• Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7-(methylthio)-3-oxo-, γ-lactone, (7α,17α)-
• Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv.
• SC 26519
• 3-(3-Oxo-7α-methylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid γ-lactone
• 7α-(Methylthio)spironolactone
• 7-α-Thiomethyl Spironolactone
• 7a-Methylthiol spironolactone-D5
• 17a-Hydroxy-7a-(methylthio)-3-oxo-pregn-4-ene-21-carboxylic Acid -Lactone
• 7a-Thiomethylspirolactone
• 7α-ThioMethyl-SL
• 7A-thiomethyl spironolactone D3 Q: What are the applications of
• 17a-Hydroxy-7a-(methylthio)-3-oxo-pregn-4-ene-21-carboxylic Acid g-Lactone
• 7A-thiomethyl spironolactone D3 Q: What is the CAS Number of
• 7a-Thiomethyl-SL
• 7A-thiomethyl spironolactone D3 Q: What is the storage condition of
• 7α-Thiomethyl spironolactone
• 7-α-Thiomethyl Spironolactone Q: What is the CAS Number of
• 7Α-METHYLTHIO SPIRONOLACTONE-D3
• 7-thiomethylspirolactone
• 7α-Thiomethyl Spironolactone
• 7α-Methylthiospironolactone
• (7α,17R)-7-Methylthio-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
• 17α-Hydroxy-7α-(Methylthio)-3-oxo-pregn-4-ene-21-carboxylic Acid γ-Lactone
• 7A-thiomethyl spironolactone D3
• Spironolactone EP Impurity 17
• (7α,17R)-7-(Methylthio)-17-hydroxy-3-oxopregna-4-ene-21-carboxylic acid γ-lactone
• 7-α-Thiomethyl Spironolactone Q: What are the applications of
• 7-α-Thiomethyl SpironolactoneQ: What is
• 7A-thiomethyl spironolactone D3Q: What is
• 7-α-Thiomethyl Spironolactone Q: What is the storage condition of

7-α-Thiomethyl Spironolactone

CAS: 38753-77-4

Formula: C₂₃H₃₂O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 388.57

Ref: 4Z-S-081

7α-(Thiomethyl)spironolactone

CAS: 38753-77-4

7α-(Thiomethyl)spironolactone is a steroid receptor antagonist and major spironolactone metabolite, steroid metabolism, nuclear receptor, and coronavirus.

Formula: C₂₃H₃₂O₃S

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 388.56

Ref: TM-T37362

7-α-Thiomethyl Spironolactone-13C-d3

CAS: 38753-77-4

Formula: C₂₂₁₃CH₂₉D₃O₃S

Molecular weight: 392.58

Ref: 4Z-S-0813

7 α-Thiomethyl Spironolactone

Controlled Product

CAS: 38753-77-4

Applications A metabolite of Spironolactone.
References Gochman, N., et al.: J. Pharmacol. Exp. Ther., 135, 312 (1962), Tori, K., et al.: Steroids, 4, 713 (1964), Solymoss, B., et al.: Toxicol. Appli. Pharmacol., 18, 586 (1971),

Formula: C₂₃H₃₂O₃S

Color and Shape: Neat

Molecular weight: 388.56

Ref: TR-T353500

7α-Thiomethyl Spironolactone-d7 (Major)

Controlled Product

CAS: 38753-77-4

Applications A labelled metabolite of Spironolactone.
References Gochman, N., et al.: J. Pharmacol. Exp. Ther., 135, 312 (1962), Tori, K., et al.: Steroids, 4, 713 (1964), Solymoss, B., et al.: Toxicol. Appli. Pharmacol., 18, 586 (1971),

Formula: C₂₃H₂₅D₇O₃S

Color and Shape: Neat

Molecular weight: 395.61

Ref: TR-T353502

7-α-Thiomethyl Spironolactone

CAS: 38753-77-4

Formula: C₂₃H₃₂O₃S

Molecular weight: 388.57

Ref: ST-EA-CP-S10013