CAS 388082-78-8

Lapatinib ditosylate monohydrate

Description:

Lapatinib ditosylate monohydrate is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of breast cancer, particularly those that are HER2-positive. It functions by inhibiting the activity of the epidermal growth factor receptor (EGFR) and HER2, thereby interfering with the signaling pathways that promote tumor growth and proliferation. This compound is characterized by its molecular formula, which includes a ditosylate component and a monohydrate form, indicating the presence of water molecules in its crystalline structure. Lapatinib is typically administered orally and is known for its moderate solubility in water, which can influence its bioavailability. The substance is often formulated in combination with other agents to enhance therapeutic efficacy. In terms of safety, it is essential to monitor for potential side effects, including gastrointestinal disturbances and skin reactions. Overall, Lapatinib ditosylate monohydrate represents a significant advancement in targeted cancer therapy, offering a mechanism of action that is distinct from traditional chemotherapy.

Formula: C₄₁H₄₀ClFN₄O₁₁S₃

InChI: InChI=1S/C29H26ClFN4O4S.C7H8O3S.H2O/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;1-6-2-4-7(5-3-6)11(8,9)10;/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2-5H,1H3,(H,8,9,10);1H2

InChI key: InChIKey=DFHHLTRPIUJKPY-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=CC(=C2)C=3OC(CNCCS(C)(=O)=O)=CC3)N=CN1)C4=CC(Cl)=C(OCC5=CC(F)=CC=C5)C=C4.S(=O)(=O)(O)C1=CC=C(C)C=C1.O

Synonyms:

• 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, 4-methylbenzenesulfonate, hydrate (1:2:1)
• Lapatinib ditosylate monohydrate
• 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, bis(4-methylbenzenesulfonate), monohydrate
• Lapatinib ditosylate hydrate
• N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) monohydrate
• benzenesulfonic acid: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine: h ydrate
• N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate)
• Lapatinib ditosylate

4-Quinazolinamine,N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, bis(4-methylbenzenesulfonate),monohydrate

CAS: 388082-78-8

Formula: C₄₃H₄₄ClFN₄O₁₁S₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 943.4761

Ref: IN-DA00I7OY

Lapatinib ditosylate monohydrate

CAS: 388082-78-8

Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.

Formula: C₂₉H₂₆ClFN₄O₄S·2(C₇H₈O₃S)·H₂O

Purity: 98% - 99.41%

Color and Shape: Colourless To Light-Yellow Crystal

Molecular weight: 943.47

Ref: TM-T0078L

Lapatinib ditosylate

CAS: 388082-78-8

Lapatinib ditosylate

Purity: 98%

Molecular weight: 925.26g/mol

Ref: 54-PC108804

Lapatinib ditosylate monohydrate

CAS: 388082-78-8

Lapatinib ditosylate monohydrate

Purity: ≥98%

Molecular weight: 943.47g/mol

Ref: 54-BUP16119

Lapatinib tosylate

CAS: 388082-78-8

Formula: C₂₉H₂₆CIFN₄O₄S·2C₇H₈O₃S

Purity: ≥ 99.0% (anhydrous substance)

Color and Shape: Yellow crystalline powder

Molecular weight: 925.46

Ref: 7W-GP0452

Lapatinib Ditosylate Monohydrate

Controlled Product

CAS: 388082-78-8

Formula: C₂₉H₂₆ClFN₄O₄S·2C₇H₈O₃S·H₂O

Color and Shape: Yellow

Molecular weight: 943.48

Ref: TR-L175813

Lapatinib Ditosylate Hydrate

CAS: 388082-78-8

Formula: C₂₉H₂₆ClFN₄O₄S(C₇H₈O₃S)H₂O

Molecular weight: 581.06 : 2(172.20) : 18.0

Ref: ST-EA-CP-L46004