CAS 38821-43-1

Levomethadyl Acetate Hydrochloride

Description:

Levomethadyl acetate hydrochloride is a synthetic opioid analgesic primarily used in the treatment of opioid dependence. It is a derivative of methadone and functions as a long-acting agonist at the mu-opioid receptor, providing pain relief and reducing withdrawal symptoms in individuals with opioid addiction. The substance is characterized by its high lipophilicity, which allows for effective penetration through biological membranes, contributing to its prolonged effects. It is typically administered in a controlled setting due to its potential for abuse and dependence. The hydrochloride salt form enhances its solubility in water, facilitating its use in various pharmaceutical formulations. As with other opioids, the use of levomethadyl acetate hydrochloride can lead to side effects such as sedation, respiratory depression, and constipation. Due to its potency and risk profile, it is classified as a controlled substance in many jurisdictions, necessitating careful monitoring and regulation in clinical practice.

Formula: C₂₃H₃₂ClNO₂

InChI: InChI=1/C23H31NO2.ClH/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21;/h7-16,18,22H,6,17H2,1-5H3;1H/t18-,22-;/m0./s1

SMILES: CC[C@@H](C(C[C@H](C)N(C)C)(c1ccccc1)c1ccccc1)OC(=O)C.Cl

Synonyms:

• Levomethadyl acetate hydrochloride [USAN]
• (-)-(3S,6S)-6-(Dimethylamino)-4,4-diphenyl-3-heptanol acetate (ester), hydrochloride
• Benzeneethanol, beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, acetate (ester), hydrochloride, (S-(R*,R*))-
• Ccris 3321
• LAAM hydrochloride
• Levacetyl methadol hydrochloride
• Levomethadyl acetate HCl
• Mk 790
• Orlaam
• alpha-l-Acetylmethadol hydrochloride
• l-Acetylmethadol hydrochloride
• l-alpha-Acetylmethadol hydrochloride
• 3-Heptanol, 6-(dimethylamino)-4,4-diphenyl-, acetate (ester), hydrochloride, (3S,6S)-(-)-
• 5-(acetyloxy)-N,N-dimethyl-4,4-diphenylheptan-2-aminium chloride

Acetylmethadol Hydrochloride (Mixture of Diastereomers)

Controlled Product

CAS: 38821-43-1

Applications Acetylmethadol Hydrochloride is a synthetic opioid similar in structure to Methadone (M225865, HCl) used in the treatment of opiate dependence. It acts as a μ-opioid receptor agonist. It also acts as a potent, noncompetitive α3β4 neuronal nicotinic acetylcholine receptor antagonist.
References Billings, R.E., et al.: Life Sci., 14, 1437 (1974); Galici, R., et al.: Pharmacol. Biochem. Behav., 81, 626 (2005); Xiao, Y., et al.: J. Pharmacol. Exp. Therap., 299, 366 (2001)

Formula: C₂₃H₃₁NO₂·HCl

Color and Shape: Neat

Molecular weight: 389.96

Ref: TR-A186330

Acetylmethadol Hydrochloride (Mixture of Diastereomers) (1mg/mL in Acetonitrile)

Controlled Product

CAS: 38821-43-1

Formula: C₂₃H₃₁NO₂·HCl

Color and Shape: Single Solution

Molecular weight: 389.96

Ref: TR-KIT2725