CAS 38916-34-6

somatostatin

Description:

Somatostatin is a peptide hormone composed of 14 amino acids, primarily known for its role in inhibiting the secretion of several other hormones, including growth hormone and insulin. It is produced in various tissues, notably the hypothalamus and the gastrointestinal tract. Somatostatin functions as a regulatory hormone, playing a crucial role in the endocrine system by modulating the activity of other hormones and neurotransmitters. Its CAS number, 38916-34-6, identifies it uniquely in chemical databases. The substance is characterized by its relatively short half-life in circulation, necessitating careful administration in therapeutic contexts. Somatostatin analogs are often used in clinical settings to manage conditions such as acromegaly, certain types of tumors, and gastrointestinal disorders. The peptide exhibits a high degree of specificity in its action, binding to somatostatin receptors, which are distributed throughout the body, influencing various physiological processes. Overall, somatostatin is a vital component of hormonal regulation, with significant implications for both health and disease management.

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

InChI: InChI=1/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)

Synonyms:

• 1: PN: US20020156010 PAGE: 3 unclaimed protein
• 15: PN: WO2007081792 SEQID: 30 claimed protein
• 15-28-Somatostatin-28
• 243: PN: EP1170021 SEQID: 2 claimed protein
• 34: PN: WO2007058336 SEQID: 34 claimed protein
• Cyclic growth hormone release-inhibiting hormone
• Cyclic ovine somatostatin
• Cyclic somatostatin
• Cyclic somatostatin-14
• Cyclic somatotropin release-inhibitor factor
• Cyclic tetradecapeptide somatostatin
• Lampetra fluviatilis somatostatin-14
• Somatostatin
• Somatostatin (Amphiuma tridactylum)
• Somatostatin (Anguilla anguilla)
• Somatostatin (Gopherus agassizii)
• Somatostatin (human)
• Somatostatin (Lophius americanus)
• Somatostatin (Myxine glutinosa)
• Somatostatin (pigeon)
• Somatostatin (rat)
• Somatostatin (sheep reduced), cyclic (3→14)-disulfide
• Somatostatin I (Lophius americanus)
• Somatostatin SS-14
• Somatostatin-14 (Gopherus agassizii)
• Somatostatin-14 (sheep)
• Somatostatina
• Somatostatine
• Sr 9357
• Sst 14
• Stilamin
• Synthetic cyclic growth hormone release-inhibiting factor
• Synthetic cyclic growth hormone release-inhibiting hormone
• Synthetic growth hormone release-inhibiting hormone
• Synthetic somatostatin-14
• Somatostatin 14
• Somatostatin Acetate
• somatostatin gamma-irradiated*cell culture tested
• H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bond)
• alanyl-N-[19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis(1-hydroxyethyl)-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide

Somatostatin 14

CAS: 38916-34-6

For cellular and molecular biology applications

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

Molecular weight: 1637.89

Ref: 02-J66168

Somatostatin-14

CAS: 38916-34-6

Somatostatin-14 (SRIF) was originally isolated from ovine hypothalamic extracts on the basis of its ability to inhibit the secretion of radioimmunoassayable growth hormone by primary cultures of enzymatically dispersed rat anterior pituitary cells. SRIF is a small cyclic neuropeptide hormone with broad inhibitory effects on endocrine secretions such as the production of GH, glucagon, and insulin.

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

Purity: 99.7%

Color and Shape: White Powder

Molecular weight: 1637.9

Ref: 01-4033009

SOMATOSTATIN CRS

CAS: 38916-34-6

SOMATOSTATIN CRS

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

Molecular weight: 1637.878

Ref: 41-S0945000

Somatostatin acetate

CAS: 38916-34-6

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

Molecular weight: 1637.89

Ref: 7W-GM7474

Somatostatin Diacetate

CAS: 38916-34-6

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂·2C₂H₄O₂

Molecular weight: 1637.90 2*60.05

Ref: 4Z-PS-219001

Somatostatin Acetate

CAS: 38916-34-6

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 1637.88

Ref: BP-BPPG058

Somatostatin Acetate

CAS: 38916-34-6

Applications Growth hormone-release inhibiting factor; treatment of severe, acute hemorrhage of gastroduodenal ulcers; experimental antidiabetic.
References Brazeau, P., et al.: Science, 179, 77 (1973), Siler, T.M., et al.: J. Clin. Endocrinol. Metab., 37, 632 (1973), Pradayrol, L., et al.: Biochem. Biophys. Res. Commun., 85, 701 (1978), Mandarino, L., et al.: Nature, 291, 76 (1981),

Formula: C₇₈H₁₀₈N₁₈O₂₁S₂

Color and Shape: Neat

Molecular weight: 1697.93

Ref: TR-S676750

Cyclic somatostatin

CAS: 38916-34-6

Cyclic somatostatin (SRIF-14) is a cyclic tetradecapeptide regulating many endocrine and nervous system functions.

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

Purity: 96.86%

Color and Shape: Powder

Molecular weight: 1637.88

Ref: TM-TP1035

Somatostatin extrapure, 97%

CAS: 38916-34-6

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

Purity: min. 97%

Color and Shape: White to off-white, Powder

Molecular weight: 1637.88

Ref: SR-54281

Somatostatin (Human, Ovine, Porcine, Rat, Mouse)

CAS: 38916-34-6

Somatostatin is a peptide hormone that has been found to inhibit pituitary growth hormone release as well as endocrine, pancreatic and GI secretions. It is widely expressed throughout the body for example in the gastrointestinal (GI) tract, hypothalamus, pancreas and the central nervous system. In the central nervous system somatostatin plays a role in neurotransmission modification and it has also demonstrated to be effective against a number of cancers such as squamous carcinoma. This product contains disulfide bonds between Cys3-Cys14 and is available as a 0.5mg vial.

Formula: C₇₆H₁₀N₁₈O₁₉S₂

Purity: Min. 95%

Molecular weight: 1,637.9 g/mol

Ref: 3D-PSI-4023-V

Somatostatin

CAS: 38916-34-6

Somatostatin is a peptide hormone that is produced by the hypothalamus and inhibits the release of growth hormones, stimulates the release of insulin from the pancreas, and inhibits the release of glucagon from the pancreas. Somatostatin also has biological properties that inhibit neuronal death in combination therapy groups. It has been shown to have cell factor activity which may contribute to its antitumor activity. Somatostatin also has pro-apoptotic properties in vitro assays at physiological levels, making it an excellent target for cancer therapy.

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

Purity: Min. 95%

Molecular weight: 1,637.9 g/mol

Ref: 3D-HOR-299

Somatostatin

CAS: 38916-34-6

Somatostatin is a polypeptide hormone that is produced by the body to inhibit the release of other hormones in the body. It has also been used to treat diseases such as carcinoid syndrome, intestinal disorders, and diabetes mellitus type I. Somatostatin binds to somatostatin receptors on cells, which leads to inhibition of cell growth and secretion of hormones. Somatostatin has been shown to block basic protein synthesis and energy metabolism in rat liver cells. Its receptor activity is mediated by binding with signal peptide sequences and response elements.

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,637.88 g/mol

Ref: 3D-FS27855

Cyclic Somatostatin

CAS: 38916-34-6

Formula: C₇₆H₁₀₄N₁₈O₁₉S₂

Purity: 97%

Color and Shape: Liquid

Molecular weight: 1637.8781599999995

Ref: IN-DA00IMLT