CAS 39024-57-2

(leu15)-gastrin I human

Description:

Gastrin I, specifically the variant known as (leu15)-gastrin I human, is a peptide hormone primarily involved in the regulation of gastric acid secretion in the stomach. It is composed of a chain of amino acids, with its structure featuring a specific sequence that includes a leucine substitution at the 15th position, which distinguishes it from other forms of gastrin. This hormone is produced by G cells in the gastric mucosa and plays a crucial role in stimulating the growth of gastric mucosa and promoting the secretion of gastric acid in response to food intake. The CAS number 39024-57-2 identifies this specific peptide in chemical databases, facilitating its study and application in research and clinical settings. Gastrin I is also involved in various physiological processes, including the regulation of gastric motility and the stimulation of pancreatic enzyme secretion. Its dysregulation can be associated with gastrointestinal disorders, making it a significant focus of medical research.

Formula: C₉₈H₁₂₆N₂₀O₃₁

InChI: InChI=1/C98H128N20O31/c1-49(2)38-68(115-96(147)72(43-55-46-101-60-19-12-10-17-58(55)60)117-98(149)74-20-13-37-118(74)77(122)48-103-86(137)61-25-31-75(120)105-61)93(144)111-66(30-36-82(131)132)92(143)110-65(29-35-81(129)130)91(142)109-64(28-34-80(127)128)90(141)108-63(27-33-79(125)126)89(140)107-62(26-32-78(123)124)88(139)104-51(5)85(136)113-70(41-53-21-23-56(119)24-22-53)87(138)102-47-76(121)106-71(42-54-45-100-59-18-11-9-16-57(54)59)95(146)114-69(39-50(3)4)94(145)116-73(44-83(133)134)97(148)112-67(84(99)135)40-52-14-7-6-8-15-52/h6-12,14-19,21-24,45,49-51,55,61-74,100-101,119H,13,20,25-44,46-48H2,1-5H3,(H2,99,135)(H,102,138)(H,103,137)(H,104,139)(H,105,120)(H,106,121)(H,107,140)(H,108,141)(H,109,142)(H,110,143)(H,111,144)(H,112,148)(H,113,136)(H,114,146)(H,115,147)(H,116,145)(H,117,149)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)

SMILES: CC(C)CC(C(=NC(CCC(=O)O)C(=NC(CCC(=O)O)C(=NC(CCC(=O)O)C(=NC(CCC(=O)O)C(=NC(CCC(=O)O)C(=NC(C)C(=NC(Cc1ccc(cc1)O)C(=NCC(=NC(Cc1c[nH]c2ccccc12)C(=NC(CC(C)C)C(=NC(CC(=O)O)C(=NC(Cc1ccccc1)C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(CC1CNc2ccccc12)N=C(C1CCCN1C(=O)CN=C(C1CCC(=N1)O)O)O)O

Synonyms:

• Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2
• (Leu15)-Gastrin I (human)

(Leu¹⁵)-Gastrin I (human)

CAS: 39024-57-2

This Gastrin I analog is as active as the native sequence, but more stable. The activity loss of Gastrin due to Met sulfoxide formation is avoided.

Formula: C₉₈H₁₂₆N₂₀O₃₁

Purity: 94.9%

Color and Shape: White Lyophilisate

Molecular weight: 2080.2

Ref: 01-4011661

[Leu15]-Gastrin I, human

CAS: 39024-57-2

[Leu15]-Gastrin I, human is a variant of Gastrin I, modulating the binding of cholecystokinin to mucosal membranes.

Formula: C₉₈H₁₂₆N₂₀O₃₁

Purity: 98.02% - 98.84%

Color and Shape: Solid

Molecular weight: 2080.16

Ref: TM-T8761

(Leu15)-Gastrin I (human)

CAS: 39024-57-2

Formula: C₉₈H₁₂₆N₂₀O₃₁

Purity: ≥ 92.0%

Color and Shape: White lyophilised solid

Molecular weight: 2080.16

Ref: 7W-GX5788

(Leu15)-Gastrin I (human)

CAS: 39024-57-2

Gastrin I (human) Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp, is a peptide that belongs to the family of cholecystokinin. It is synthesized by solid phase synthesis on a carboxyl group with an efficiency of more than 95%. Gastrin I (human) Pyr-Gly-Pro-Trp... has been shown to be selective towards amide bond cleavage and has high yield. It is also stable in acidic conditions and can be detritylated with phenoxy.

Formula: C₉₈H₁₂₆N₂₀O₃₁

Purity: Min. 95%

Molecular weight: 2,080.17 g/mol

Ref: 3D-FL108876