CAS 39025-24-6

(-)-(E)-Guggulsterone

Description:

(-)-(E)-Guggulsterone, with the CAS number 39025-24-6, is a naturally occurring steroidal compound derived from the resin of the Commiphora mukul tree, commonly known as guggul. This compound is characterized by its dual isomeric forms, with the (-)-(E) configuration being biologically active. Guggulsterone is known for its potential therapeutic properties, particularly in traditional medicine, where it has been used for its anti-inflammatory and lipid-lowering effects. Chemically, it features a steroid backbone with specific functional groups that contribute to its biological activity. The compound has garnered interest in pharmacological research for its role in modulating cholesterol levels and its potential effects on metabolic disorders. Additionally, guggulsterone has been studied for its possible anticancer properties and its influence on thyroid function. Its solubility and stability can vary depending on the formulation, which is important for its application in dietary supplements and herbal remedies. Overall, (-)-(E)-Guggulsterone represents a significant compound in both traditional and modern medicinal contexts.

Formula: C₂₁H₂₈O₂

InChI: InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4-/t15-,17+,18+,20+,21-/m1/s1

InChI key: InChIKey=WDXRGPWQVHZTQJ-AUKWTSKRSA-N

SMILES: C[C@@]1/2[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC(=O)\C2=C\C)[H]

Synonyms:

• (-)-(E)-Guggulsterone
• (17E)-Pregna-4,17(20)-diene-3,16-dione
• (17E)-pregna-4,17-diene-3,16-dione
• 4,17(20)-(trans)-Pregnadiene-3,16-dione
• E-Guggulsteron
• Guggulsterone E
• trans-Guggulsterone
• Pregna-4,17(20)-diene-3,16-dione, (17E)-

Pregna-4,17(20)-diene-3,16-dione, (17E)-

CAS: 39025-24-6

Formula: C₂₁H₂₈O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 312.4458

Ref: IN-DA0076LS

(E)-Guggulsterone

CAS: 39025-24-6

Formula: C₂₁H₂₈O₂

Purity: ≥ 95.0%

Color and Shape: White to off-white powder

Molecular weight: 312.45

Ref: 7W-GL4238

(E)-Guggulsterone

CAS: 39025-24-6

Formula: C₂₁H₂₈O₂

Purity: 95%~99%

Molecular weight: 312.453

Ref: BP-BP1402

(E)-Guggulsterone

CAS: 39025-24-6

Bile acids aid fat digestion, originate from cholesterol, activate FXR, and can be toxic. Guggulsterone inhibits FXR and lowers rodent cholesterol.

Formula: C₂₁H₂₈O₂

Color and Shape: Solid

Molecular weight: 312.45

Ref: TM-T36563

(E)-Guggulsterone

CAS: 39025-24-6

Formula: C₂₁H₂₈O₂

Molecular weight: 312.45

Ref: 4Z-G-212001

Guggulsterone e

CAS: 39025-24-6

Alicyclic ketone

Formula: C₂₁H₂₈O₂

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Crystals

Molecular weight: 312.45

Ref: 5G-89698

(E)-Guggulsterone

Controlled Product

CAS: 39025-24-6

Applications (E)-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.
References Yang, D. et al.: J. Lipid Res., 53, 529 (2012); El-Mekkawy, S. et al.: Nat. Prod. Res., 27, 146 (2013);

Formula: C₂₁H₂₈O₂

Color and Shape: White To Off-White

Molecular weight: 312.45

Ref: TR-G852005

(E)-Guggulsterone

Controlled Product

CAS: 39025-24-6

(E)-Guggulsterone is a phytosteroid, which is a bioactive compound derived from the resin of the Commiphora mukul tree, commonly known as the guggul plant. Its mode of action primarily involves antagonism of the farnesoid X receptor (FXR), a bile acid receptor, which plays a crucial role in cholesterol metabolism and bile acid homeostasis. By inhibiting FXR, (E)-Guggulsterone increases the conversion of cholesterol to bile acids, thus promoting the reduction of cholesterol levels.

Formula: C₂₁H₂₈O₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 312.45 g/mol

Ref: 3D-FG39357