CAS 39026-92-1: 9-Methoxycamptothecin

Description: 9-Methoxycamptothecin is a synthetic derivative of camptothecin, a compound originally isolated from the bark of the Chinese tree Camptotheca acuminata. This substance is characterized by its unique structure, which includes a methoxy group at the 9-position of the indole ring, enhancing its solubility and biological activity. It exhibits potent antitumor properties, primarily through its mechanism of action as a topoisomerase I inhibitor, which interferes with DNA replication and transcription, leading to cell death in rapidly dividing cancer cells. 9-Methoxycamptothecin has shown promise in preclinical studies for various cancers, including colorectal and lung cancers. Its pharmacokinetic profile indicates favorable absorption and distribution, although its stability can be a concern due to the lactone ring, which can hydrolyze under certain conditions. Research continues to explore its efficacy and safety in clinical settings, as well as potential formulations to enhance its therapeutic index. Overall, 9-Methoxycamptothecin represents a significant area of interest in cancer chemotherapy development.

Formula: C₂₁H₁₈N₂O₅

InChI: InChI=1S/C21H18N2O5/c1-3-21(26)14-8-16-18-11(7-12-15(22-18)5-4-6-17(12)27-2)9-23(16)19(24)13(14)10-28-20(21)25/h4-8,26H,3,9-10H2,1-2H3/t21-/m0/s1

InChI key: InChIKey=XVMZDZFTCKLZTF-NRFANRHFSA-N

SMILES: O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=CC=C(OC)C5=CC4C3

Synonyms:

• (4S)-4-Ethyl-4-hydroxy-10-methoxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4-ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-9-methoxy-, (S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (S)-
• 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (4S)-
• 9-Methoxycamptothecin
• 9-Methoxycamptothecine
• NSC 176323

9-Methoxycamptothecin

CAS: 39026-92-1

• Formula: C₂₁H₁₈N₂O₅
• Molecular weight: 378.38

9-Methoxycamptothecin

CAS: 39026-92-1

• Formula: C₂₁H₁₈N₂O₅
• Purity: 95%~99%
• Molecular weight: 378.384

(S)-9-Methoxy Camptothecin

CAS: 39026-92-1

• Formula: C₂₁H₁₈N₂O₅
• Molecular weight: 378.38

9-Methoxycamptothecin

CAS: 39026-92-1

9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.

• Formula: C₂₁H₁₈N₂O₅
• Purity: 98.49% - 99.55%
• Color and Shape: Solid
• Molecular weight: 378.38

9-Methoxycamptothecin

CAS: 39026-92-1

• Formula: C₂₁H₁₈N₂O₅
• Color and Shape: Neat
• Molecular weight: 323.987

10-Methoxycamptothecine

CAS: 39026-92-1

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• Purity: Min. 95%