CAS 39028-27-8

Iodoacetic acid N-hydroxysuccinimide ester

Description:

Iodoacetic acid N-hydroxysuccinimide ester, with the CAS number 39028-27-8, is a chemical compound commonly used in bioconjugation and protein labeling applications. This compound features an iodoacetic acid moiety, which is known for its ability to react with thiol groups in proteins, facilitating the formation of stable thioether bonds. The N-hydroxysuccinimide (NHS) component enhances the reactivity of the ester, allowing for efficient coupling to amine-containing molecules, such as amino acids or proteins. The NHS ester is particularly valued for its ability to form stable amide bonds upon reaction with primary amines, making it a versatile tool in biochemistry and molecular biology. Iodoacetic acid N-hydroxysuccinimide ester is typically used in the development of targeted drug delivery systems, fluorescent labeling, and the synthesis of bioconjugates for various research applications. It is important to handle this compound with care due to the presence of iodine, which can be hazardous, and to follow appropriate safety protocols during its use.

Formula: C₆H₆INO₄

InChI: InChI=1/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2

InChI key: InChIKey=VRDGQQTWSGDXCU-UHFFFAOYSA-N

SMILES: O(C(CI)=O)N1C(=O)CCC1=O

Synonyms:

• (2,5-Dioxopyrrolidin-1-yl) 2-iodoacetate
• 1-[(Iodoacetyl)Oxy]Pyrrolidine-2,5-Dione
• 2,5-Pyrrolidinedione, 1-[(iodoacetyl)oxy]-
• Acetic acid, 2-iodo-, 2,5-dioxo-1-pyrrolidinyl ester
• N-Hydroxysuccinimide iodoacetate
• N-Hydroxysuccinimide iodoacetic acid ester
• N-Hydroxysuccinimidyl iodoacetate
• N-Iodoacetoxysuccinimide
• N-Succinimidyl iodoacetate
• SIA (crosslinking agent)
• Iodoacetic acid-N-hydroxysuccinimide ester
• Succinimidyl iodoacetate
• SIA
• Iodoacetic Acid N-Succinimidyl Ester
• N-SucciniMidyl iodoacetate(SIA)
• SIA Crosslinker
• NHS IODOACETATE
• N-(Iodoacetoxy)succinimide

2,5-Dioxopyrrolidin-1-yl 2-iodoacetate

CAS: 39028-27-8

Formula: C₆H₆INO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 283.0206

Ref: IN-DA003R0M

N-Hydroxysuccinimidyl iodoacetate

CAS: 39028-27-8

N-Hydroxysuccinimidyl iodoacetate

Formula: C₆H₆INO₄

Purity: 95%

Color and Shape: White Powder

Molecular weight: 283.02g/mol

Ref: 54-BICL214

SIA Crosslinker

CAS: 39028-27-8

SIA Crosslinker is a non-cleavable ADC linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].

Formula: C₆H₆INO₄

Purity: 98%

Color and Shape: White Solid

Molecular weight: 283.02

Ref: TM-T16880

N-Succinimidyl Iodoacetate

CAS: 39028-27-8

Formula: C₆H₆INO₄

Purity: >95.0%(N)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 283.02

Ref: 3B-S0844

N-Succinimidyl iodoacetate

CAS: 39028-27-8

Amine and sulfhydryl reactive crosslinker

Formula: C₆H₆INO₄

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 283.02 g/mol

Ref: 3D-FS27902

Iodoacetic acid N-hydroxysuccinimide ester

CAS: 39028-27-8

Formula: C₆H₆INO₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 283.021

Ref: 10-F038187