CAS 39069-52-8

N,N'-dicyclopentyl-2-(methylsulfanyl)-5-nitropyrimidine-4,6-diamine

Description:

N,N'-Dicyclopentyl-2-(methylsulfanyl)-5-nitropyrimidine-4,6-diamine, with the CAS number 39069-52-8, is a chemical compound characterized by its complex structure, which includes a pyrimidine ring substituted with various functional groups. The presence of two cyclopentyl groups contributes to its hydrophobic characteristics, while the methylsulfanyl group introduces a sulfur atom, enhancing its potential for specific interactions in biological systems. The nitro group at the 5-position of the pyrimidine ring may impart unique reactivity and influence the compound's electronic properties. This compound is likely to exhibit moderate to low solubility in water due to its bulky cyclopentyl substituents, but it may dissolve in organic solvents. Its structural features suggest potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways. However, detailed studies on its biological activity, toxicity, and environmental impact would be necessary to fully understand its characteristics and potential uses.

Formula: C₁₅H₂₃N₅O₂S

InChI: InChI=1/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19)

InChI key: InChIKey=GSGVDKOCBKBMGG-UHFFFAOYSA-N

SMILES: N(C=1C(N(=O)=O)=C(NC2CCCC2)N=C(SC)N1)C3CCCC3

Synonyms:

• 4,6-Pyrimidinediamine, N,N′-dicyclopentyl-2-(methylthio)-5-nitro-
• 4,6-Pyrimidinediamine, N⁴,N⁶-dicyclopentyl-2-(methylthio)-5-nitro-
• 4,6-Pyrimidinediamine, N~4~,N~6~-dicyclopentyl-2-(methylthio)-5-nitro-
• Gs 39783
• N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine
• N⁴,N⁶-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
• N4,N6-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
• 4,6-Pyrimidinediamine, N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-
• N,N'-Dicyclopentyl-2-(methylsulfanyl)-5-nitropyrimidine-4,6-diamine
• N4,N6-Dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine
• N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediaamine

GS 39783

CAS: 39069-52-8

Formula: C₁₅H₂₃N₅O₂S

Purity: 95%

Color and Shape: Solid

Molecular weight: 337.4404

Ref: IN-DA00C0BL

GS 39783

CAS: 39069-52-8

GS 39783

Purity: ≥98%

Molecular weight: 337.44g/mol

Ref: 54-BUP01200

GS 39783-d8

Controlled Product

CAS: 39069-52-8

Formula: C₁₅D₈H₁₅N₅O₂S

Color and Shape: Neat

Molecular weight: 345.49

Ref: TR-G797152

GS 39783

Controlled Product

CAS: 39069-52-8

Applications GS 39783 is an allosteric positive modulator of GABAB receptors. GS 39783 attenuates acute cocaine-induced hyperlocomotion and blocks cocaine-induced Fos induction in the striatal complex.
References Paterson, N. et al.: J. Pharmacol. Exp. Ther., 326, 306 (2008); Mombereau, C. et al.: J. Pharmacol. Exp. Ther., 321, 172 (2007); Lhuillier, L. et al.: Neuropsychopharmacol., 32, 388 (2007); Slattery, D. et al.: Neuropharmacol., 30, 2065 (2005)

Formula: C₁₅H₂₃N₅O₂S

Color and Shape: Neat

Molecular weight: 337.44

Ref: TR-G797150

GS 39783-d8

CAS: 39069-52-8

GS 39783-d8 is a baclofen analogue that has been shown to bind to the GABA receptor and is an agonist at this receptor. GS 39783-d8 has been shown to have a synergistic effect with other drugs, such as amitriptyline, in experimental models of inflammatory skin diseases. It has also been shown to inhibit cancer cell growth in prostate cancer cells. The pharmacokinetic properties of GS 39783-d8 are similar to those of baclofen, with a half-life of 2 hours and no active metabolites. This agent has also been shown to be effective against symptoms associated with Parkinson's disease and may have therapeutic potential for other neurological disorders.

Formula: C₁₅H₁₅D₈N₅O₂S

Purity: Min. 95%

Molecular weight: 345.49 g/mol

Ref: 3D-PBA06952

GS 39783

CAS: 39069-52-8

GS 39783 is a positive allosteric modulator (PAM) of GABABR, which reduces the motivational properties of alcohol and the conditioned reinforcement and

Formula: C₁₅H₂₃N₅O₂S

Purity: 99.92%

Color and Shape: Solid

Molecular weight: 337.44

Ref: TM-T22813