CAS 391-12-8

7-Trifluoroisatin

Description:

7-Trifluoroisatin, with the CAS number 391-12-8, is a chemical compound that belongs to the class of isatins, which are derived from indole and characterized by a diketone structure. This particular compound features a trifluoromethyl group at the 7-position of the isatin ring, which significantly influences its chemical properties and reactivity. 7-Trifluoroisatin is typically a solid at room temperature and exhibits a pale yellow to light brown color. It is known for its potential applications in medicinal chemistry, particularly in the development of pharmaceuticals due to its biological activity, including antimicrobial and anticancer properties. The presence of the trifluoromethyl group enhances lipophilicity and metabolic stability, making it an interesting target for drug design. Additionally, 7-Trifluoroisatin can participate in various chemical reactions, including nucleophilic substitutions and cycloadditions, which are valuable in synthetic organic chemistry. As with many fluorinated compounds, it is important to handle 7-Trifluoroisatin with care, considering its potential environmental and health impacts.

Formula: C₉H₄F₃NO₂

InChI: InChI=1/C9H4F3NO2/c10-9(11,12)5-3-1-2-4-6(5)13-8(15)7(4)14/h1-3H,(H,13,14,15)

SMILES: c1cc2c(c(c1)C(F)(F)F)NC(=O)C2=O

Synonyms:

• Buttpark 24\07-40
• 7-(Trifluoromethyl)Indoline-2,3-Dione
• 7-(Trifluoromethyl)Isatin
• 7-(Trifluoromethyl)-1H-Indole-2,3-Dione
• 7-(Trifluoromethyl)Indole-2,3-Dione

7-(Trifluoromethyl)isatin

CAS: 391-12-8

Formula: C₉H₄F₃NO₂

Purity: >98.0%(GC)(T)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 215.13

Ref: 3B-T2457

7-(Trifluoromethyl)indoline-2,3-dione

CAS: 391-12-8

Formula: C₉H₄F₃NO₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 215.1288

Ref: IN-DA003NC9

7-(Trifluoromethyl)isatin

CAS: 391-12-8

7-(Trifluoromethyl)isatin

Purity: 98%

Color and Shape: Solid

Molecular weight: 215.13g/mol

Ref: 54-PC1776

7-Trifluoromethylisatin

CAS: 391-12-8

Formula: C₉H₄F₃NO₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 215.131

Ref: 10-F024866

7-(Trifluoromethyl)-1H-indole-2,3-dione-d2

Controlled Product

CAS: 391-12-8

Applications 7-(Trifluoromethyl)1H-indole-2,3-dione-d2 is a labelled 7-(Trifluoromethyl)1H-indole-2,3-dione (T791300), an inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer's disease.
References Medwid, J., et al.: J. Med. Chem., 33, 1230 (1990), Collins, L., et al.: Antimicrob. Agents Chemother., 41, 1004 (1997), Dandia, A., et al.: Bioorg. Med. Chem., 14, 2409 (2006)

Formula: C₉D₂H₂F₃NO₂

Color and Shape: Neat

Molecular weight: 217.141

Ref: TR-T791302

7-(Trifluoromethyl)1H-indole-2,3-dione

CAS: 391-12-8

Trifluoromethyl-substituted 7-(trifluoromethyl)1H-indole-2,3-dione is a trifluoromethyl analogue of indole-2,3-dione that has been shown to have antimalarial activity. It has been shown to be active against plasmodium and cancer cells in vitro. Trifluoromethyl group can be replaced by other substituents such as methoxy, ethoxy, or nitro groups. The compound has centrosymmetric structures and an elemental composition of C8H4F3N.

Formula: C₉H₄F₃NO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 215.13 g/mol

Ref: 3D-FT28468

7-(Trifluoromethyl)1H-indole-2,3-dione

Controlled Product

CAS: 391-12-8

Applications An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer's disease.
References Medwid, J., et al.: J. Med. Chem., 33, 1230 (1990), Collins, L., et al.: Antimicrob. Agents Chemother., 41, 1004 (1997), Dandia, A., et al.: Bioorg. Med. Chem., 14, 2409 (2006),

Formula: C₉H₄F₃NO₂

Color and Shape: Neat

Molecular weight: 215.13

Ref: TR-T791300