Description:7-Trifluoroisatin, with the CAS number 391-12-8, is a chemical compound that belongs to the class of isatins, which are derived from indole and characterized by a diketone structure. This particular compound features a trifluoromethyl group at the 7-position of the isatin ring, which significantly influences its chemical properties and reactivity. 7-Trifluoroisatin is typically a solid at room temperature and exhibits a pale yellow to light brown color. It is known for its potential applications in medicinal chemistry, particularly in the development of pharmaceuticals due to its biological activity, including antimicrobial and anticancer properties. The presence of the trifluoromethyl group enhances lipophilicity and metabolic stability, making it an interesting target for drug design. Additionally, 7-Trifluoroisatin can participate in various chemical reactions, including nucleophilic substitutions and cycloadditions, which are valuable in synthetic organic chemistry. As with many fluorinated compounds, it is important to handle 7-Trifluoroisatin with care, considering its potential environmental and health impacts.
Applications 7-(Trifluoromethyl)1H-indole-2,3-dione-d2 is a labelled 7-(Trifluoromethyl)1H-indole-2,3-dione (T791300), an inhibitor of COX-1, COX-2, and β-catenin. Useful …
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