CAS 391210-10-9

N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide

Description:

N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide, with CAS number 391210-10-9, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple functional groups such as amides, fluorine, and iodine substituents. This compound features a benzamide core, which is modified by the presence of difluoro and iodo groups, contributing to its potential biological activity. The dihydroxypropoxy moiety suggests that it may exhibit hydrophilic properties, enhancing its solubility in polar solvents. The presence of halogens, particularly fluorine and iodine, often influences the compound's reactivity and pharmacokinetic properties, making it of interest in medicinal chemistry. Such compounds are typically investigated for their potential therapeutic applications, including anti-cancer or anti-inflammatory activities. Additionally, the stereochemistry indicated by the (2R) configuration may play a crucial role in the compound's biological interactions and efficacy. Overall, this compound exemplifies the intricate design often found in drug development, where specific substitutions are made to optimize desired properties.

Formula: C₁₆H₁₄F₃IN₂O₄

InChI: InChI=1/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1

InChI key: InChIKey=SUDAHWBOROXANE-SECBINFHSA-N

SMILES: N(C1=C(C(NOC[C@@H](CO)O)=O)C=CC(F)=C1F)C2=C(F)C=C(I)C=C2

Synonyms:

• Benzamide, N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-
• Mirdametinib
• N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
• N-[((R)-2,3-Dihydroxypropyl)oxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
• N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
• N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
• Pd 0325901
• Pd 03525901
• Pd 325901
• Pd 901
• Pd325901
• N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]be
• N-[(R)-2,3-Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylaMino)-benzaMide
• (R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide
• PD-0235901

Mirdametinib

CAS: 391210-10-9

Formula: C₁₆H₁₄F₃IN₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 482.1930

Ref: IN-DA0037IF

Mirdametinib (PD 0325901)

CAS: 391210-10-9

Formula: C₁₆H₁₄F₃IN₂O₄

Molecular weight: 482.20

Ref: 4Z-M-329001

Mirdametinib

CAS: 391210-10-9

Mirdametinib

Purity: ≥98%

Molecular weight: 482.19g/mol

Ref: 54-BUP15010

PD 0325901

CAS: 391210-10-9

Formula: C₁₆H₁₄F₃IN₂O₄

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 482.20

Ref: 3B-P2897

Mirdametinib

CAS: 391210-10-9

Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.

Formula: C₁₆H₁₄F₃IN₂O₄

Purity: 99.11% - 99.63%

Color and Shape: White Powder

Molecular weight: 482.19

Ref: TM-T6189

PD0325901

CAS: 391210-10-9

PD0325901

Formula: C₁₆H₁₄F₃IN₂O₄

Purity: 99.88% (lc-ms) (Typical Value in Batch COA)

Color and Shape: white to off-white solid

Molecular weight: 482.19g/mol

Ref: 54-BISN0215

PD 0325901

CAS: 391210-10-9

Formula: C₁₆H₁₄F₃IN₂O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 482.19

Ref: 7W-GL5463

PD 0325901

CAS: 391210-10-9

A potent non ATP-competitive inhibitor of MAP/ERK kinase (MEK). Has anti-tumor activity in melanoma and papillary thyroid cancer cells with B-Raf mutations. Enhances generation and survival of induced pluripotent stem cells (iPSCs).

Formula: C₁₆H₁₄F₃IN₂O₄

Purity: Min. 95%

Molecular weight: 482.19 g/mol

Ref: 3D-FP26781

rac-PD-325901-d5

Controlled Product

CAS: 391210-10-9

Formula: C₁₆D₅H₉F₃IN₂O₄

Color and Shape: Neat

Molecular weight: 487.224

Ref: TR-P217452

PD 0325901

CAS: 391210-10-9

Formula: C₁₆H₁₄F₃IN₂O₄

Molecular weight: 482.20

Ref: 4Z-PF-0003