CAS 39178-35-3

Isonicotinoyl chloride hydrochloride

Description:

Isonicotinoyl chloride hydrochloride is a chemical compound that belongs to the class of acyl chlorides, specifically derived from isonicotinic acid. It is characterized by its reactivity due to the presence of the acyl chloride functional group, which makes it a useful intermediate in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals. The compound typically appears as a white to off-white solid and is soluble in polar organic solvents. It is important to handle isonicotinoyl chloride hydrochloride with care, as it can be corrosive and may release hydrochloric acid upon hydrolysis. The compound is often used in the synthesis of isonicotinoyl derivatives, which have applications in medicinal chemistry, particularly in the development of anti-tuberculosis agents and other therapeutic compounds. Safety precautions should be observed when working with this substance, including the use of appropriate personal protective equipment and working in a well-ventilated area or fume hood.

Formula: C₆H₄ClNO·ClH

InChI: InChI=1S/C6H4ClNO.ClH/c7-6(9)5-1-3-8-4-2-5;/h1-4H;1H

InChI key: InChIKey=BNTRVUUJBGBGLZ-UHFFFAOYSA-N

SMILES: C(Cl)(=O)C=1C=CN=CC1.Cl

Synonyms:

• (Chlorocarbonyl)-4-(pyridinyl) monohydrochloride
• 4-(Chloroformyl)pyridinium hydrochloride
• 4-Nicotinoyl chloride hydrochloride
• 4-Pyridinecarbonyl chloride, hydrochloride
• 4-Pyridinecarbonyl chloride, hydrochloride (1:1)
• 4-Pyridinecarboxylic acid chloride hydrochloride
• 4-Pyridinoyl Chloride Hydrochloride
• Isonicotinic acid chloride hydrochloride
• Isonicotinoyl Chloride Hydrochloride
• Isonicotinoyl Chloride Hydrochloride, 95 %
• Isonicotinoyl Chloride Hydrochloride,Pyridine-4-Carbonyl Chloride
• IsonicotinoylchlorideHCl
• Isonicotinyl Chloride Hydrochloride
• Pyridine-4-Carbonyl Chloride Hydrochloride
• Pyridine-4-Carbonyl Chloride Hydrochloride (1:1)
• Pyridine-4-carbonylchlorideHCl
• Timtec-Bb Sbb003768

Isonicotinoyl chloride hydrochloride, 97%

CAS: 39178-35-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₆H₅Cl₂NO

Purity: 97%

Color and Shape: White to cream to pale brown or pale yellow, Crystalline powder

Molecular weight: 178.01

Ref: 02-A10863

Isonicotinoyl chloride hydrochloride

CAS: 39178-35-3

Formula: C₆H₅Cl₂NO

Purity: 95%

Color and Shape: Solid

Molecular weight: 178.0160

Ref: IN-DA003R41

Isonicotinoyl Chloride Hydrochloride

CAS: 39178-35-3

Formula: C₆H₄ClNO·HCl

Purity: >95.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 178.01

Ref: 3B-I0144

Isonicotinoyl chloride hydrochloride

CAS: 39178-35-3

Isonicotinoyl chloride hydrochloride

Formula: C₆H₄ClNO·ClH

Purity: 95%

Color and Shape: white powder

Molecular weight: 178.02g/mol

Ref: 54-OR23065

Isonicotinyl Chloride Hydrochloride

Controlled Product

CAS: 39178-35-3

Stability Sensitive to moisture
Applications Isonicotinyl Chloride Hydrochloride, is a heterocyclic building block used for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the preparation of Tetrahydropyrroloquinolinone type dual inhibitors of Aromatase/Aldosterone Synthase, as a novel stagey for breast cancer patients with the risk of cardiovascular diseases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yin, L., et al.: J. Med. Chem., 56 (2), 460 (2013);

Formula: C₆H₅Cl₂NO

Color and Shape: Neat

Molecular weight: 178.02

Ref: TR-I821755

Isonicotinoyl chloride hydrochloride

CAS: 39178-35-3

Isonicotinoyl chloride HCl is a macrocyclic inhibitor of the nuclear hormone receptor (NR) that belongs to the class of organic compounds. It is used in the treatment of inflammatory diseases and infectious diseases. Isonicotinoyl chloride HCl has been shown to inhibit nitric oxide synthase, which leads to an inhibition of inflammatory reactions in various tissues. This compound also inhibits p. aeruginosa and alkylthio group, which may be due to its coordination geometry or aromatic hydrocarbon. Isonicotinoyl chloride HCl binds to mineralocorticoid receptors on cells and blocks their transcriptional activity, thereby inhibiting inflammation and oxidative stress.

Formula: C₆H₄ClNO•HCl

Purity: Min. 95%

Color and Shape: White To Beige Solid

Molecular weight: 178.02 g/mol

Ref: 3D-FI29482

Isonicotinoyl chloride hydrochloride

CAS: 39178-35-3

Formula: C₆H₅Cl₂NO

Purity: 95%

Color and Shape: Solid, White to almost white powder

Molecular weight: 178.01

Ref: 10-F066672