CAS 3926-67-8

8-Chloro-10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-ol

Description:

8-Chloro-10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-ol, with the CAS number 3926-67-8, is a chemical compound belonging to the phenothiazine class, which is characterized by a tricyclic structure containing sulfur and nitrogen atoms. This compound features a chloro substituent at the 8-position and a dimethylaminopropyl side chain at the 10-position, contributing to its pharmacological properties. It is known for its potential use in medicinal chemistry, particularly in the development of antipsychotic and antidepressant agents. The presence of the hydroxyl group at the 2-position enhances its solubility and reactivity. The compound exhibits a range of biological activities, including antipsychotic effects, which are attributed to its ability to interact with various neurotransmitter receptors in the brain. Its chemical stability and lipophilicity are also notable, influencing its bioavailability and distribution in biological systems. As with many phenothiazines, safety and toxicity profiles are important considerations in its application and handling.

Formula: C₁₇H₁₉ClN₂OS

InChI: InChI=1S/C17H19ClN2OS/c1-19(2)8-3-9-20-14-10-12(18)4-6-16(14)22-17-7-5-13(21)11-15(17)20/h4-7,10-11,21H,3,8-9H2,1-2H3

InChI key: InChIKey=UBUDVAYGFVRZCO-UHFFFAOYSA-N

SMILES: C(CCN(C)C)N1C=2C(SC=3C1=CC(O)=CC3)=CC=C(Cl)C2

Synonyms:

• 10H-Phenothiazin-2-ol, 8-chloro-10-[3-(dimethylamino)propyl]-
• 8-Hydroxychlorpromazine
• Phenothiazin-2-ol, 8-chloro-10-[3-(dimethylamino)propyl]-
• 8-Chloro-10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-ol

8-Hydroxy Chlorpromazine

CAS: 3926-67-8

Formula: C₁₇H₁₉ClN₂OS

Color and Shape: Off-White Solid

Molecular weight: 334.86

Ref: 4Z-C-125009

8-Hydroxychlorpromazine-d6 Hydrochloride

Controlled Product

CAS: 3926-67-8, 51938-10-4

Formula: C₁₇D₆H₁₃ClN₂OS·HCl

Color and Shape: Neat

Molecular weight: 377.361

Ref: TR-H824907

8-Hydroxy Chlorpromazine

CAS: 3926-67-8

Formula: C₁₇H₁₉ClN₂OS

Molecular weight: 334.86

Ref: ST-EA-CP-C19029

8-Hydroxychlorpromazine

CAS: 3926-67-8

8-Hydroxychlorpromazine is a metabolite of Chlorpromazine that can enhance the hyperglycemic response following glucose loading, suggesting a possible synergistic role in Chlorpromazine-induced glucose metabolism disorders. It holds potential for research into metabolic diseases.

Formula: C₁₇H₁₉ClN₂OS

Color and Shape: Solid

Molecular weight: 334.864

Ref: TM-T206182