CAS 393105-53-8

Tiplaxtinin

Description:

Tiplaxtinin, identified by its CAS number 393105-53-8, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is classified as a small molecule and is known for its role as a selective inhibitor of certain biological pathways, which may contribute to its efficacy in treating specific diseases. The compound exhibits a unique molecular structure that influences its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion. Tiplaxtinin has been studied for its interactions with various biological targets, which may include enzymes or receptors involved in disease processes. Its safety profile and side effects are also critical areas of research, as they determine its viability for clinical use. Overall, Tiplaxtinin represents a promising candidate in drug development, with ongoing studies aimed at elucidating its full therapeutic potential and mechanism of action.

Formula: C₂₄H₁₆F₃NO₄

InChI: InChI=1S/C24H16F3NO4/c25-24(26,27)32-18-9-6-16(7-10-18)17-8-11-21-19(12-17)20(22(29)23(30)31)14-28(21)13-15-4-2-1-3-5-15/h1-12,14H,13H2,(H,30,31)

InChI key: InChIKey=ODXQFEWQSHNQNI-UHFFFAOYSA-N

SMILES: C(C(O)=O)(=O)C=1C=2C(N(CC3=CC=CC=C3)C1)=CC=C(C2)C4=CC=C(OC(F)(F)F)C=C4

Synonyms:

• 1H-Indole-3-acetic acid, α-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-
• 1H-indole-3-acetic acid, alpha-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-
• Pai 039
• Tiplasinin
• Tiplaxtinin
• α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid

1H-Indole-3-aceticacid, a-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-

CAS: 393105-53-8

Formula: C₂₄H₁₆F₃NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 439.3833

Ref: IN-DA0038QW

Tiplaxtinin

CAS: 393105-53-8

Tiplaxtinin

Purity: ≥98%

Molecular weight: 439.38g/mol

Ref: 54-BUP13025

Tiplaxtinin

CAS: 393105-53-8

Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.

Formula: C₂₄H₁₆F₃NO₄

Purity: 99.16% - 99.93%

Color and Shape: Solid

Molecular weight: 439.38

Ref: TM-T2030

Tiplaxtinin

Controlled Product

CAS: 393105-53-8

Applications Tiplaxtinin inhibits smooth muscle cells (SMC) migration and intimal hyperplasia. A novel therapeutic agent to improve diabetic wound.
References Ji, Y., et al.: Arterioscler. Thromb. Vasc. Biol., 36, 2167-2175 (2016); Rebalka, I. A., et al.: Diabetes, 64, 2593-2602 (2015)

Formula: C₂₄H₁₆F₃NO₄

Color and Shape: Neat

Molecular weight: 439.38

Ref: TR-T444895

Tiplaxtinin

Controlled Product

CAS: 393105-53-8

Tiplaxtinin is a natural drug that has been shown to have anti-cancer activity in vitro and in vivo. It has been found to inhibit the activity of polymerase chain reaction (PCR) by binding to the enzyme DNA polymerase, thereby preventing the formation of new strands of DNA. Tiplaxtinin also inhibits the production of MDA-MB-231 breast cancer cells, which may be due to its ability to bind toll-like receptor 4 (TLR4). The anti-cancer effects are also mediated by its ability to induce pai-1, a protein that regulates apoptosis and cellular differentiation. Tiplaxtinin is a biocompatible polymer because it is an ester linkages with glucose injection, which can be used for oral administration.

Formula: C₂₄H₁₆F₃NO₄

Purity: Min. 95%

Molecular weight: 439.38 g/mol

Ref: 3D-FT103155