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CAS 39366-37-5

:

Ethinylestradiol-levonorgestrel mixt.

Description:
Ethinylestradiol-levonorgestrel mixt, commonly referred to as a combination oral contraceptive, consists of two active ingredients: ethinylestradiol, a synthetic estrogen, and levonorgestrel, a synthetic progestin. This combination is primarily used in hormonal contraceptives to prevent ovulation and regulate menstrual cycles. Ethinylestradiol is known for its ability to inhibit the release of gonadotropins, thereby preventing ovulation, while levonorgestrel enhances the effectiveness of contraception by thickening cervical mucus and altering the endometrial lining to prevent implantation. The substance is typically administered in tablet form and is characterized by its hormonal activity, which can also influence secondary sexual characteristics and menstrual regulation. Common side effects may include nausea, headaches, and mood changes, and it is contraindicated in certain conditions such as thromboembolic disorders. The pharmacokinetics of this mixture involves absorption through the gastrointestinal tract, with metabolism primarily occurring in the liver. Overall, this combination is widely used for its efficacy in preventing pregnancy and managing various menstrual disorders.
Formula:C21H28O2·C20H24O2
InChI:InChI=1S/C21H28O2.C20H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2;1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h2,13,16-19,23H,3,5-12H2,1H3;1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17+,18+,19-,20-,21-;16-,17-,18+,19+,20+/m01/s1
InChI key:InChIKey=ORKBYCQJWQBPFG-WOMZHKBXSA-N
SMILES:C(C)[C@@]12[C@]([C@]3([C@](CC1)([C@@]4(C(CC3)=CC(=O)CC4)[H])[H])[H])(CC[C@]2(C#C)O)[H].C[C@@]12[C@]([C@]3([C@](CC1)(C=4C(CC3)=CC(O)=CC4)[H])[H])(CC[C@]2(C#C)O)[H]
Synonyms:
  • Nordette
  • 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-, mixt. with (17α)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol
  • Trinordiol
  • Trigynon
  • Levonorgestrel-ethynylestradiol mixt.
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