CAS 3947-65-7
:Neamine
Description:
Neamine, with the CAS number 3947-65-7, is a chemical compound that belongs to the class of aminoglycoside antibiotics. It is derived from the antibiotic neomycin and is characterized by its structure, which includes multiple amino groups that contribute to its biological activity. Neamine exhibits antibacterial properties, primarily effective against a range of Gram-negative and some Gram-positive bacteria. Its mechanism of action involves binding to the bacterial ribosome, inhibiting protein synthesis, which ultimately leads to cell death. Neamine is soluble in water, which facilitates its use in various pharmaceutical formulations. Additionally, it is important to note that, like other aminoglycosides, neamine can have nephrotoxic and ototoxic effects, necessitating careful monitoring during therapeutic use. The compound is also of interest in research for its potential applications in drug development and as a lead compound for synthesizing new antibiotics. Overall, neamine is a significant substance in the field of medicinal chemistry, particularly in the context of antibiotic resistance and the search for novel antimicrobial agents.
Formula:C12H26N4O6
InChI:InChI=1S/C12H26N4O6/c13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h3-12,17-20H,1-2,13-16H2/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m1/s1
InChI key:InChIKey=SYJXFKPQNSDJLI-HKEUSBCWSA-N
SMILES:O([C@H]1[C@H](O)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N
Synonyms:- 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine
- Neamine
- Neamin
- Neomycin A
- D-Streptamine, 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-
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Found 12 products.
Neomycin A
CAS:<p>Sugars, chemically pure, other than sucrose, lactose, maltose, glucose and fructose; sugar ethers and sugar esters, and their salts, nesoi</p>Formula:C12H26N4O6(freebase)Color and Shape:Off-White Yellow PowderMolecular weight:322.18523(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
CAS:Formula:C12H26N4O6Purity:%Color and Shape:SolidMolecular weight:322.3580Neamine
CAS:<p>Neamine: antibiotic, anti-angiogenic, battles bacteria, cancer, protects nerves.</p>Formula:C12H26N4O6Color and Shape:SolidMolecular weight:322.36Neomycin Sulfate EP Impurity A (Neamine)
CAS:Formula:C12H26N4O6Color and Shape:White To Off-White SolidMolecular weight:322.36Neamine
CAS:<p>Stability Hygroscopic<br>Applications Neamine is normally found as a core structure of aminoglycoside antibiotics. It is used in the synthesis of disaccharide neamine derivatives as antibacterial agents.<br>References Kawaguchi, H., et al.: J. Antibiot., 25, 695 (1972), Fourmy, D., et al.: Science, 274, 1367 (1996), Riguet, E., et al.: J. Med. Chem., 47, 4806 (2004)<br></p>Formula:C12H26N4O6Color and Shape:White To Light YellowMolecular weight:322.36Neamine Disulfate Salt
CAS:<p>Stability Hygroscopic<br>Applications Neamine is normally found as a core structure of aminoglycoside antibiotics. It is used in the synthesis of disaccharide neamine derivatives as antibacterial agents.<br>References Kawaguchi, H., et al.: J. Antibiot., 25, 695 (1972), Fourmy, D., et al.: Science, 274, 1367 (1996), Riguet, E., et al.: J. Med. Chem., 47, 4806 (2004)<br></p>Formula:C12H30N4O14S2Color and Shape:NeatMolecular weight:518.52Neamine
CAS:<p>Neamine is an antimicrobial agent that is a derivative of trifluoroacetic acid. It has been shown to have antibacterial activity against Gram-positive and Gram-negative bacteria and minimal toxicity in a variety of animal models, including mice, rats, hamsters, and guinea pigs. Neamine is also not toxic to human cells. Neamine may be useful for the treatment of microbial infections in humans because it blocks bacterial protein synthesis by inhibiting the action of proteases, which are enzymes that cleave peptide bonds in proteins. Neamine also binds to toll-like receptor 4 (TLR4) on human epithelial cells, which may play a role in the treatment of bowel disease. Neamine has been shown to inhibit the activity of carbohydrate chemistry enzymes such as α-amylase and α-glucosidase.</p>Formula:C12H26N4O6Purity:Min. 95%Color and Shape:White PowderMolecular weight:322.36 g/mol
