CAS 394730-60-0

Boceprevir

Description:

Boceprevir is an antiviral medication primarily used in the treatment of chronic hepatitis C virus (HCV) infection. It belongs to a class of drugs known as protease inhibitors, which work by inhibiting the HCV NS3/4A protease enzyme, essential for viral replication. Boceprevir is typically administered in combination with other antiviral agents to enhance its efficacy and reduce the likelihood of resistance. The compound has a molecular formula that reflects its complex structure, which includes multiple functional groups contributing to its pharmacological activity. Boceprevir is characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can influence its bioavailability. The drug is metabolized primarily in the liver, and its pharmacokinetics are affected by factors such as liver function and concomitant medications. Common side effects may include fatigue, anemia, and gastrointestinal disturbances. Due to its specific mechanism of action and side effect profile, Boceprevir is an important option in the therapeutic landscape for hepatitis C, particularly in treatment-experienced patients.

Formula: C₂₇H₄₅N₅O₅

InChI: InChI=1S/C27H45N5O5/c1-25(2,3)20(30-24(37)31-26(4,5)6)23(36)32-13-15-17(27(15,7)8)18(32)22(35)29-16(19(33)21(28)34)12-14-10-9-11-14/h14-18,20H,9-13H2,1-8H3,(H2,28,34)(H,29,35)(H2,30,31,37)/t15-,16?,17-,18-,20+/m0/s1

InChI key: InChIKey=LHHCSNFAOIFYRV-DOVBMPENSA-N

SMILES: C(NC(CC1CCC1)C(C(N)=O)=O)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(NC(C)(C)C)=O)C(C)(C)C)=O)[H])[H]

Synonyms:

• (1R,2S,5S)-N-(4-Amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• (1R,2S,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
• 3-Azabicyclo[3.1.0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-, (1R,2S,5S)-
• Boceprevirertet
• Ebp 520
• Sch 503034
• Victrelis
• Boceprevir

Boceprevir

CAS: 394730-60-0

Boceprevir

Purity: ≥95%

Molecular weight: 519.68g/mol

Ref: 54-BUP13257

Boceprevir

CAS: 394730-60-0

Boceprevir (SCH 503034), an oral HCV NS3 protease inhibitor, has a Ki of 14 nM and EC90 of 350 nM.

Formula: C₂₇H₄₅N₅O₅

Purity: 95% - 99.16%

Color and Shape: Solid

Molecular weight: 519.68

Ref: TM-T4988

Boceprevir

CAS: 394730-60-0

Formula: C₂₇H₄₅N₅O₅

Molecular weight: 519.69

Ref: 4Z-B-531

Boceprevir

CAS: 394730-60-0

Boceprevir

Formula: C₂₇H₄₅N₅O₅

Purity: 98% (Typical Value in Batch COA)

Color and Shape: white solid

Molecular weight: 519.68g/mol

Ref: 54-BISN0326

Boceprevir

CAS: 394730-60-0

Formula: C₂₇H₄₅N₅O₅

Purity: ≥ 98.0%

Color and Shape: White to light-yellow powder

Molecular weight: 519.68

Ref: 7W-GP0844

Boceprevir (>90%)

Controlled Product

CAS: 394730-60-0

Formula: C₂₇H₄₅N₅O₅

Purity: >90%

Color and Shape: Neat

Molecular weight: 519.68

Ref: TR-B674500

Boceprevir

CAS: 394730-60-0

Boceprevir is a peptidomimetic, covalent inhibitor of NS3/4A serine protease from hepatitis C virus (HCV). Boceprevir also inhibits and acts as a substrate in the cytochrome P450 3A4 (CYP3A) metabolic pathway. Boceprevir was recently shown to inhibit the main protease Mpro (3CLpro) from SARS-CoV-2 with IC50 of 4.13 μM and EC50 of 1.31 μM.

Formula: C₂₇H₄₅N₅O₅

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 519.68 g/mol

Ref: 3D-FB18939