CAS 39552-01-7

Befunolol

Description:

Befunolol is a non-selective beta-adrenergic antagonist, primarily used in the treatment of glaucoma and ocular hypertension. It functions by reducing intraocular pressure through the inhibition of aqueous humor production. The chemical structure of Befunolol includes a phenolic group and a secondary amine, contributing to its pharmacological activity. It is characterized by its ability to penetrate the corneal barrier, which enhances its efficacy in ophthalmic applications. Befunolol exhibits a relatively low systemic absorption when administered topically, minimizing systemic side effects commonly associated with beta-blockers. Additionally, it has antioxidant properties, which may provide additional benefits in ocular health. The substance is typically formulated as eye drops and is known for its relatively favorable safety profile, although potential side effects can include local irritation or allergic reactions. As with any medication, it is essential to use Befunolol under the guidance of a healthcare professional to ensure appropriate dosing and monitoring for adverse effects.

Formula: C₁₆H₂₁NO₄

InChI: InChI=1/C16H21NO4/c1-10(2)17-8-13(19)9-20-14-6-4-5-12-7-15(11(3)18)21-16(12)14/h4-7,10,13,17,19H,8-9H2,1-3H3

InChI key: InChIKey=ZPQPDBIHYCBNIG-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=C2C(C=C(C(C)=O)O2)=CC=C1

Synonyms:

• Befunolol
• (±)-Befunolol
• 2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran
• Ethanone, 1-[7-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2-benzofuranyl]-
• 1-[7-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-2-benzofuranyl]ethanone
• 1-(7-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2-benzofuranyl)-ethanon
• (+)-2-Acetyl-7-[(R)-2-hydroxy-3-isopropylaminopropoxy]benzofuran
• (-)-2-Acetyl-7-[(S)-2-hydroxy-3-isopropylaminopropoxy]benzofuran
• 2-acetyl-7-(2-hyroxy-3-isopropylaminopropoxy)benzofuran
• ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl
• 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl ketone

Befunolol

Controlled Product

CAS: 39552-01-7

Applications Befunolol is a β-adrenergic blocker with an intrinsic sympathomimetic action. But it can work as a β-adrenergic partial agonist in isolated organs.
References Nakano, J., et al.: Chem. Pharm. Bull., 36, 1399 (1988); Takayanagi, I., et al.: Gen. Pharmacol., 20, 417 (1989); Koike, K., et al.: Gen. Pharmacol., 25, 1477 (1994)

Formula: C₁₆H₂₁NO₄

Color and Shape: White To Off-White

Molecular weight: 291.34

Ref: TR-B131100

Befunolol-d7

Controlled Product

CAS: 39552-01-7

Formula: C₁₆D₇H₁₄NO₄

Color and Shape: Neat

Molecular weight: 298.385

Ref: TR-B131102

(±)-Befunolol

CAS: 39552-01-7

(±)-Befunolol is a blocking agent of β-adrenoceptor.

Formula: C₁₆H₂₁NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 291.34

Ref: TM-T13982