CAS 39563-28-5

Cloranolol

Description:

Cloranolol, identified by its CAS number 39563-28-5, is a beta-adrenergic antagonist, primarily used in the treatment of hypertension and certain cardiac conditions. It exhibits selectivity for beta-1 adrenergic receptors, which are predominantly found in the heart, leading to a decrease in heart rate and myocardial contractility. This compound is characterized by its ability to reduce blood pressure and alleviate symptoms associated with heart failure. Cloranolol's pharmacological profile includes properties such as antiarrhythmic effects and potential benefits in managing anxiety-related symptoms. The substance is typically administered orally and is metabolized in the liver, with its effects lasting several hours. As with other beta-blockers, it may have side effects, including fatigue, dizziness, and gastrointestinal disturbances. Its use should be monitored, especially in patients with respiratory conditions or diabetes, due to the potential for adverse reactions. Overall, Cloranolol represents a valuable option in cardiovascular pharmacotherapy, contributing to improved patient outcomes in managing heart-related ailments.

Formula: C₁₃H₁₉Cl₂NO₂

InChI: InChI=1S/C13H19Cl2NO2/c1-13(2,3)16-7-10(17)8-18-12-6-9(14)4-5-11(12)15/h4-6,10,16-17H,7-8H2,1-3H3

InChI key: InChIKey=XYCMOTOFHFTUIU-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)(C)C)O)C1=C(Cl)C=CC(Cl)=C1

Synonyms:

• (RS)-1-tert-Butylamino-3-(2,5-dichlorphenoxy)-2-propanol
• 1-(2,5-Dichlorophenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol
• 1-(Tert-Butylamino)-3-(2,5-Dichlorophenoxy)Propan-2-Ol
• 1-(tert-Butylamino)-3-(2,5-dichlorophenoxy)-2-propanol
• 2-Propanol, 1-(2,5-dichlorophenoxy)-3-((1,1-dimethylethyl)amino)-
• Chloranolol
• Cloranolol [INN]
• Cloranololum
• Cloranololum [INN-Latin]
• Gyki 41099
• Tobanum

Chloranolol

Controlled Product

CAS: 39563-28-5

Applications Chloranolol is a β-adrenergic blocher. Chloranolol is used as an antiarrhythmic.
References Tenyi, I., et al.: Curr. Ther. Res., 21, 823 (1977), Tomori, E., et al.: J. Chromatogr., 204, 355 (1981), Anzali, S., et al.: J. Med. Chem., 44, 2432 (2001),

Formula: C₁₃H₁₉Cl₂NO₂

Color and Shape: Neat

Molecular weight: 292.20

Ref: TR-C325350

Cloranolol

CAS: 39563-28-5

Cloranolol is a long-acting beta-blocker.

Formula: C₁₃H₁₉Cl₂NO₂

Color and Shape: Solid

Molecular weight: 292.2

Ref: TM-T69302