CAS 39620-02-5

5-Bromonicotinoyl chloride

Description:

5-Bromonicotinoyl chloride is an organic compound characterized by the presence of a bromine atom and an acyl chloride functional group attached to a nicotinic acid derivative. It typically appears as a colorless to pale yellow liquid or solid, depending on its purity and form. The compound is known for its reactivity, particularly due to the acyl chloride functional group, which can readily participate in nucleophilic substitution reactions. This makes it a valuable intermediate in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals. The presence of the bromine atom can also enhance its reactivity and influence its biological activity. As with many acyl chlorides, 5-bromonicotinoyl chloride is sensitive to moisture and should be handled under anhydrous conditions to prevent hydrolysis. Safety precautions are essential when working with this compound, as it can be corrosive and may cause irritation to the skin, eyes, and respiratory system. Proper storage and handling protocols should be followed to ensure safety in laboratory environments.

Formula: C₆H₃BrClNO

InChI: InChI=1/C6H3BrClNO/c7-5-1-4(6(8)10)2-9-3-5/h1-3H

SMILES: c1c(cncc1Br)C(=O)Cl

Synonyms:

• 5-Bromopyridine-3-carbonyl chloride

5-Bromonicotinoyl chloride

CAS: 39620-02-5

Formula: C₆H₃BrClNO

Purity: 95%

Color and Shape: Solid

Molecular weight: 220.4511

Ref: IN-DA003MKO

5-Bromonicotinoyl chloride

CAS: 39620-02-5

5-Bromonicotinoyl chloride

Formula: C₆H₃BrClNO

Purity: ≥95%

Color and Shape: white crystalline powder

Molecular weight: 220.45g/mol

Ref: 54-OR26792

Nicergoline Impurity 11

CAS: 39620-02-5

Formula: C₆H₃BrClNO

Molecular weight: 220.45

Ref: 4Z-N-070027

5-Bromonicotinoyl chloride

CAS: 39620-02-5

Formula: C₆H₃BrClNO

Purity: 97%

Color and Shape: Solid

Molecular weight: 220.45

Ref: 10-F066675

5-Bromonicotinoyl chloride

CAS: 39620-02-5

5-Bromonicotinoyl chloride is a synthetic compound that has been shown to be an inhibitor of some cancer cells. This compound has been shown to inhibit the enzyme phosphatidylinositol 3-kinase (PI3K) in a specific ligand-dependent manner. The precise mechanism of action is not yet understood, but it is thought that 5-bromonicotinoyl chloride may bind to the enzyme and inhibit its activity by hydrogen bonding interactions. This product inhibits PI3K, which is responsible for generating phosphatidylinositol 3,4,5-triphosphate (PIP3). PIP3 activates protein kinase B (AKT), which promotes cell proliferation and inhibits apoptosis. It also inhibits the enzyme phosphodiesterase type 4 (PDE4), which controls intracellular levels of cyclic GMP. PDE4 activity leads to vasodilation and platelet aggregation.

Formula: C₆H₃BrClNO₂

Purity: Min. 95%

Molecular weight: 236.54 g/mol

Ref: 3D-FB02811

Nicergoline Impurity 11

CAS: 39620-02-5

Formula: C₆H₃BrClNO

Molecular weight: 220.45

Ref: ST-EA-CP-N39027