CAS 396716-14-6

DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS;

Description:

DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS is a peptide-based compound commonly used in biochemical research, particularly in fluorescence resonance energy transfer (FRET) applications. This substance consists of a donor (EDANS) and an acceptor (DABCYL) moiety, which allows for the study of molecular interactions and conformational changes in peptides and proteins. The peptide sequence includes various amino acids, contributing to its structural and functional properties. DABCYL serves as a quencher, while EDANS acts as a fluorescent reporter, making this compound valuable for monitoring enzymatic activity, protein folding, and other dynamic biological processes. The presence of multiple serine and arginine residues may influence the peptide's solubility and interaction with other biomolecules. Overall, DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS is a versatile tool in molecular biology and biochemistry, facilitating the exploration of complex biological systems through its unique fluorescence characteristics.

Formula: C₇₀H₁₀₄N₂₂O₁₈S

Synonyms:

• Adam-17 Substrate Ii, Fluorogenic
• Adam-17 Substrate Iii, Fluorogenic
• Dabcyl-Tnf-Alpha-Edans (-4 To +6) (Human)
• Dabcyl-Tumor Necrosis Factor-Alpha-Edans (-4 To +6) (Human)
• Dabcyl-Laqavrsssr-Edans
• Tnf-Alpha Convertase Enzyme Substrate, Fluorogenic
• Tnf-Alpha Convertase Enzyme Substrate Ii, Fluorogenic
• L-Argininamide, N-[4-[[4-(Dimethylamino)Phenyl]Azo]Benzoyl]-L-Leucyl-L-Alanyl-L-Glutaminyl-L-Alanyl-L-Valyl-L-Arginyl-L-Seryl-L-Seryl-L-Seryl-N-[2-[(5-Sulfo-1-Naphthalenyl)Amino]Ethyl]-
• Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Edans

Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Edans

CAS: 396716-14-6

TNF-a is shed from cell membranes by TNF-a-FW cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-α converting enzyme (TACE, ADAM17 endopeptidase) activity. On application is its use as a TACE FRET Substrate I and it is available as a Trifluoroacetate Salt.

Formula: C₇₀H₁₀₄N₂₂O₁₈S

Purity: Min. 95%

Molecular weight: 1,573.81 g/mol

Ref: 3D-SFQ-3764-PI

DABCYL-TNF-α-EDANS (-4 to +6) (human) trifluoroacetate salt

CAS: 396716-14-6

DABCYL-TNF-alpha-EDANS (-4 to +6) (human) trifluoroacetate salt is a fine chemical that has been shown to be useful in research. It is a versatile building block for the synthesis of complex compounds and can be used as a reaction component for the synthesis of speciality chemicals. The compound is a high quality reagent, which can be used as an intermediate for the synthesis of other chemical compounds.

Formula: C₇₀H₁₀₄N₂₂O₁₈S·C₂HF₃O₂

Purity: Min. 95%

Color and Shape: Red Solid

Molecular weight: 1,687.8 g/mol

Ref: 3D-FD110922