CAS 39746-25-3

16,16-Dimethyl-PGE2

Description:

16,16-Dimethyl-PGE2 is a synthetic analog of prostaglandin E2 (PGE2), which is a bioactive lipid involved in various physiological processes, including inflammation, vasodilation, and regulation of gastric mucosa. This compound is characterized by the presence of two methyl groups at the 16 position of the prostaglandin structure, which alters its biological activity and stability compared to natural PGE2. It exhibits potent effects on various biological systems, often being used in research to study prostaglandin pathways and their implications in health and disease. The modification at the 16 position enhances its resistance to enzymatic degradation, making it a valuable tool in pharmacological studies. Additionally, 16,16-Dimethyl-PGE2 can influence cellular signaling pathways, impacting processes such as cell proliferation and apoptosis. Its unique structure allows it to interact with specific receptors, providing insights into the role of prostaglandins in physiological and pathological conditions. As with many prostaglandin analogs, it is essential to handle this compound with care due to its potent biological effects.

Formula: C₂₂H₃₆O₅

InChI: InChI=1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,19-,20-/m1/s1

InChI key: InChIKey=QAOBBBBDJSWHMU-WMBBNPMCSA-N

SMILES: C(=C/[C@H](C(CCCC)(C)C)O)\[C@@H]1[C@@H](C/C=C\CCCC(O)=O)C(=O)C[C@H]1O

Synonyms:

• (5E,8beta,11beta,12xi,13E,15R)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1-oic acid
• (5Z,11-alpha,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1-oic acid
• (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1-oic acid
• 16,16-Dimethyl-PGE₂
• 16,16-Dimethyl-pge2
• 16,16-Dimethyl-prostaglandin E2
• 16,16-Dimethylprostaglandin E₂
• 5-Heptenoic acid, 7-(2-(4,4-dimethyl-3-hydroxy-1-octenyl)-3-hydroxy-5-oxocyclopentyl)-
• 7-(2-(4,4-Dimethyl-3-hydroxy-1-octenyl)-3-hydroxy-5-oxocyclopentyl)-5-heptenoic acid
• Brn 2896843
• Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (5Z,11-alpha,13E,15R)-
• Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (5Z,11α,13E,15R)-
• MeSH ID: D015064

16,16-Dimethyl prostaglandin E2 methyl acetate solution

CAS: 39746-25-3

16,16-Dimethyl prostaglandin E2 is a metabolite of 16,16-dimethyl prostaglandin E2. It is produced by the oxidation of 16,16-dimethyl prostaglandin and is involved in the regulation of inflammatory responses. 16,16-Dimethyl prostaglandin E2 has been shown to induce antibody production by stimulating the immune system in mice. In other studies, this metabolite was found to have no effect on locomotor activity or food intake. The effects of 16,16-dimethyl prostaglandin E2 on animals with radiation injuries are unclear because it has not been tested in vivo. This metabolite also inhibits liver cell growth when administered to rats at high doses.

Formula: C₂₂H₃₆O₅

Purity: Min. 95%

Molecular weight: 380.52 g/mol

Ref: 3D-BD177551

16,16-Dimethyl prostaglandin E2

CAS: 39746-25-3

16,16-Dimethyl prostaglandin E2 regulates hematopoietic stem cells via EP2/EP4 and Wnt, taken orally.

Formula: C₂₂H₃₆O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 380.52

Ref: TM-T10046