CAS 3978-86-7: Azatadine maleate

Description: Azatadine maleate is an antihistamine primarily used for the treatment of allergic conditions. It is classified as a first-generation antihistamine, which means it can cross the blood-brain barrier and may cause sedation as a side effect. The substance is a salt formed from azatadine and maleic acid, enhancing its solubility and stability. Azatadine itself acts as an antagonist to histamine H1 receptors, thereby alleviating symptoms associated with allergies, such as sneezing, itching, and runny nose. In addition to its antihistaminic properties, azatadine may exhibit anticholinergic effects, which can contribute to its therapeutic profile but also lead to side effects like dry mouth and urinary retention. The compound is typically administered orally and is available in various formulations. As with many medications, it is essential to consider potential interactions with other drugs and contraindications in specific populations, such as pregnant or breastfeeding individuals. Overall, azatadine maleate is a valuable option in managing allergic reactions, though its sedative effects necessitate caution in certain situations.

Formula: C₂₀H₂₂N₂·2C₄H₄O₄

InChI: InChI=1S/C20H22N2.C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19;5-3(6)1-2-4(7)8/h2-7,12H,8-11,13-14H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: InChIKey=KGCJWSUJYBJBBW-BTJKTKAUSA-N

SMILES: O=C(O)C=CC(=O)O.N1=CC=CC2=C1C(C=3C=CC=CC3CC2)=C4CCN(C)CC4

Synonyms:

• 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine dimaleate
• 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine di[(2Z)-but-2-enedioate]
• 5-(4′-N-Methylpiperidylidene)-4-azo-10:11-dihydrodibenzocycloheptene dimaleate
• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (2Z)-2-butenedioate (1:2)
• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (Z)-2-butenedioate (1:2)
• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidylidene)-, maleate (1:2)
• Atoramin
• Azatadine Maleate
• Bonamid
• Idulian
• Optimine
• Sch 10649
• Trinalin
• Zadine

AZATADINE MALEATE (200 MG)

CAS: 3978-86-7

• Formula: C₂₈H₃₀N₂O₈
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 522.5464

Azatadine dimaleate

CAS: 3978-86-7

Azatadine dimaleate (SCH10649) is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM).

• Formula: C₂₈H₃₀N₂O₈
• Purity: 100% - 99.70%
• Color and Shape: Powder
• Molecular weight: 522.55

Azatadine Dimaleate

CAS: 3978-86-7

• Formula: C₂₀H₂₂N₂C₄H₄O₄
• Molecular weight: 290.41 2 116.07

Azatadine dimaleate

CAS: 3978-86-7

• Purity: 99.7%
• Molecular weight: 522.55g/mol

Azatadine maleate

CAS: 3978-86-7

• Purity: 98%
• Molecular weight: 522.55g/mol

Azatadine Dimaleate

CAS: 3978-86-7

Applications Antihistaminic. References Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008), De …

• Formula: C₂₀H₂₂N₂C₄H₄O₄
• Color and Shape: White To Off-White
• Molecular weight: 522.55

Azatadine dimaleate

CAS: 3978-86-7

Azatadine is an antihistamine that has been shown to be clinically relevant for the treatment …

• Formula: C₂₀H₂₂N₂·2C₄H₄O₄
• Purity: Min. 95%
• Molecular weight: 522.55 g/mol