CAS 3978-86-7

Azatadine maleate

Description:

Azatadine maleate is an antihistamine primarily used for the treatment of allergic conditions. It is classified as a first-generation antihistamine, which means it can cross the blood-brain barrier and may cause sedation as a side effect. The substance is a salt formed from azatadine and maleic acid, enhancing its solubility and stability. Azatadine itself acts as an antagonist to histamine H1 receptors, thereby alleviating symptoms associated with allergies, such as sneezing, itching, and runny nose. In addition to its antihistaminic properties, azatadine may exhibit anticholinergic effects, which can contribute to its therapeutic profile but also lead to side effects like dry mouth and urinary retention. The compound is typically administered orally and is available in various formulations. As with many medications, it is essential to consider potential interactions with other drugs and contraindications in specific populations, such as pregnant or breastfeeding individuals. Overall, azatadine maleate is a valuable option in managing allergic reactions, though its sedative effects necessitate caution in certain situations.

Formula: C₂₀H₂₂N₂·2C₄H₄O₄

InChI: InChI=1S/C20H22N2.C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19;5-3(6)1-2-4(7)8/h2-7,12H,8-11,13-14H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: InChIKey=KGCJWSUJYBJBBW-BTJKTKAUSA-N

SMILES: CN1CCC(=C2C=3C(CCC=4C2=NC=CC4)=CC=CC3)CC1.C(=C\C(O)=O)\C(O)=O

Synonyms:

• 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine dimaleate
• 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine di[(2Z)-but-2-enedioate]
• 5-(4′-N-Methylpiperidylidene)-4-azo-10:11-dihydrodibenzocycloheptene dimaleate
• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (2Z)-2-butenedioate (1:2)
• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (Z)-2-butenedioate (1:2)
• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidylidene)-, maleate (1:2)
• Atoramin
• Azatadine Maleate
• Bonamid
• Idulian
• Optimine
• Sch 10649
• Trinalin

Azatadine Maleate

CAS: 3978-86-7

Formula: C₂₈H₃₀N₂O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 522.5464

Ref: IN-DA00C6EC

Azatadine dimaleate

CAS: 3978-86-7

Azatadine dimaleate (SCH10649) is an inhibitor for histamine（IC50=6.5 nM） and cholinergic（IC50=10 nM）.

Formula: C₂₈H₃₀N₂O₈

Purity: 99.7% - >99.99%

Color and Shape: Powder

Molecular weight: 522.55

Ref: TM-T0236

Azatadine maleate

CAS: 3978-86-7

Azatadine maleate

Purity: 98%

Molecular weight: 522.55g/mol

Ref: 54-OR1027832

Azatadine dimaleate

CAS: 3978-86-7

Azatadine dimaleate

Purity: ≥98%

Molecular weight: 522.55g/mol

Ref: 54-BUP11880

Azatadine Dimaleate

CAS: 3978-86-7

Formula: C₂₀H₂₂N₂·2C₄H₄O₄

Molecular weight: 290.41 2 116.07

Ref: 4Z-A-105001

Azatadine Dimaleate

Controlled Product

CAS: 3978-86-7

Applications Antihistaminic.
References Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008), De Graw, A., et al.: J. Med. Chem., 53, 2464 (2010), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010),

Formula: C₂₀H₂₂N₂·2C₄H₄O₄

Color and Shape: White To Off-White

Molecular weight: 522.55

Ref: TR-A802950

Azatadine Dimaleate

CAS: 3978-86-7

Formula: C₂₀H₂₂N₂(C₄H₄O₄)

Molecular weight: 290.41 : 2(116.07)

Ref: ST-EA-CP-A253000