CAS 398001-88-2

L-Cysteine,L-isoleucyl-L-valyl-L-leucyl-L-seryl-L-leucyl-L-a-aspartyl-L-valyl-L-prolyl-L-isoleucylglycyl-L-leucyl-L-leucyl-L-glutaminyl-L-isoleucyl-L-leucyl-L-leucyl-L-a-glutamyl-L-glutaminyl-L-alanyl-L-arginyl-L-alanyl-L-arginyl-L-alanyl-L-alanyl-L-argin

Description:

The substance you are referring to, with the name "L-Cysteine, L-isoleucyl-L-valyl-L-leucyl-L-seryl-L-leucyl-L-a-aspartyl-L-valyl-L-prolyl-L-isoleucylglycyl-L-leucyl-L-leucyl-L-glutaminyl-L-isoleucyl-L-leucyl-L-leucyl-L-a-glutamyl-L-glutaminyl-L-alanyl-L-arginyl-L-alanyl-L-arginyl-L-alanyl-L-alanyl-L-argin" and CAS number 398001-88-2, is a complex peptide composed of multiple amino acids. This compound features a sequence that includes various L-amino acids, which are the building blocks of proteins. The presence of L-cysteine suggests that it may have thiol groups, which can participate in redox reactions and form disulfide bonds, contributing to the stability and structure of proteins. The sequence indicates a potential for diverse biological activity, possibly influencing protein folding, enzyme activity, or cellular signaling pathways. However, due to its complexity and length, specific functional characteristics would depend on its conformation and interactions within biological systems. As with many peptides, its solubility, stability, and reactivity can vary based on environmental conditions such as pH and temperature.

Formula: C₁₉₆H₃₄₀F₃N₆₃O₅₆S

Synonyms:

• 3:PN: WO0212307 SEQID: 3 claimed protein
• Human urocortin 2
• Urocortin II(human)
• Urocortin-related peptide (human)
• Stresscopin-Related Peptide (6-43) (Human) Trifluoroacetate Salt
• UROCORTIN II (HUMAN) TRIFLUOROACETATE SALT
• Ucn II (huMan), Stresscopin-Related Peptide (6-43)-Gly-His-Cys-NH2 (huMan)
• H-ILE-VAL-LEU-SER-LEU-ASP-VAL-PRO-ILE-GLY-LEU-LEU-GLN-ILE-LEU-LEU-GLU-GLN-ALA-ARG-ALA-ARG-ALA-ALA-ARG-GLU-GLN-ALA-THR-THR-ASN-ALA-ARG-ILE-LEU-ALA-ARG-VAL-GLY-HIS-CYS-NH2
• STRESSCOPIN-RELATED PEPTIDE (6-43) (HUMAN) TRIFLUOROACETATE
• Urocortin II (human), CRF2 agonist
• ILE-VAL-LEU-SER-LEU-ASP-VAL-PRO-ILE-GLY-LEU-LEU-GLN-ILE-LEU-LEU-GLU-GLN-ALA-ARG-ALA-ARG-ALA-ALA-ARG-GLU-GLN-ALA-THR-THR-ASN-ALA-ARG-ILE-LEU-ALA-ARG-VAL-GLY-HIS-CYS-NH2
• UCN II (HUMAN)
• UCN II (HUMAN) TRIFLUOROACETATE SALT

Urocortin II, Human

CAS: 398001-88-2

For cellular and molecular biology applications

Formula: C₁₉₄H₃₃₈N₆₃O₅₄S

Color and Shape: White to off-white, Lyophilized Powder

Molecular weight: 4449.27

Ref: 02-J66900

Urocortin II (human)

CAS: 398001-88-2

Ucn II (human), a new member of the CRF family of neuropeptides, binds selectively to the type 2 CRF receptor (CRF-R2), with no appreciable activity on CRF-R1.

Formula: C₁₉₄H₃₃₉N₆₃O₅₄S

Purity: 97.1%

Color and Shape: White Lyophilisate

Molecular weight: 4450.28

Ref: 01-4040984

Urocortin II (human) TFA

CAS: 398001-88-2

Urocortin II, a neuropeptide hormone within the corticotropin-releasing factor (CRF) family—which comprises mammalian CRF, urocortin I, urocortin III, frog sauvagine, and piscine urotensin I—displays 34, 43, and 37-40% sequence homology with rat and human CRF, human urocortin I, and human urocortin III, respectively. This compound enhances rabbit ventricular myocyte shortening and relaxation in both a time- and concentration-dependent manner. In vivo studies reveal that urocortin II lowers arterial blood pressure in both normotensive and spontaneously hypertensive rats through peripheral CRF2 receptor agonism, inducing dose-dependent tachycardia and hypotension at doses of 3 and 30 pmol/kg. Additionally, it mitigates the visceral pain response to colorectal distension at 10 and 20 μg/kg in conscious rats and delays gastric emptying in mice.

Formula: C₁₉₆H₃₄₀F₃N₆₃O₅₆S

Color and Shape: Solid

Molecular weight: 4564.32

Ref: TM-T85181