CAS 39831-55-5

Amikacin sulfate

Description:

Amikacin sulfate is an aminoglycoside antibiotic used primarily to treat serious infections caused by Gram-negative bacteria, particularly in cases where other antibiotics may be ineffective. It is a semi-synthetic derivative of kanamycin and exhibits a broad spectrum of antibacterial activity. The chemical structure of amikacin sulfate includes an amino group that enhances its efficacy against resistant strains. It is typically administered via injection and is known for its relatively low toxicity compared to other aminoglycosides, although it can still cause nephrotoxicity and ototoxicity. The substance is soluble in water, which facilitates its use in clinical settings. Amikacin sulfate is often used in combination with other antibiotics to enhance therapeutic outcomes, especially in severe infections such as those caused by Pseudomonas aeruginosa. Its pharmacokinetics involve renal excretion, necessitating dosage adjustments in patients with impaired kidney function. Overall, amikacin sulfate remains a critical option in the antibiotic arsenal, particularly for multidrug-resistant infections.

Formula: C₂₂H₄₇N₅O₂₁S₂

InChI: InChI=1/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1

InChI key: InChIKey=HIBICIOPDUTNRR-XTHCGPPUSA-N

SMILES: O([C@H]1[C@H](NC([C@H](CCN)O)=O)C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]1O)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O.S(=O)(=O)(O)O

Synonyms:

• (2R)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (salt)
• (2S)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (1:2)
• (2S)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (salt)
• 4-Amino-N-[5-Amino-2-[4-Amino-3,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydropyran-2-Yl]Oxy-4-[6-(Aminomethyl)-3,4,5-Trihydroxy-Tetrahydropyran-2-Yl]Oxy-3-Hydroxy-Cyclohexyl]-2-Hydroxy-Butanamide Disulfate Salt
• 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-N¹-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-, sulfate (1:2) (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-N¹-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-, sulfate (1:2)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-N¹-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-, sulfate (1:2) (salt)
• Amiglyde V
• Amika
• Amikacin Disulfate Salt
• Amikacin Sulfate
• Amikacin Sulfate 1:1.8
• Amikacin Sulfate Salt
• Amikacin disulfate
• Amikavet
• Amikin
• Amiklin
• Antibiotic BB-K 8 sulfate
• Arikayce liposomal
• Biklin
• Biodacyn
• Biodacyna
• Fabianol
• Grasil
• Kaminax
• Mikavir
• Novamin
• Pierami
• Selemycin
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-, sulfate (1:2) (salt)
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-, sulfate (1:2) (salt)
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-, sulfate (1:2)
• antibioticbb-k8sulfate
• (s)-ysulfate(1:2)(salt)
• AMIKACIN SULFATE, PHARMA
• AmikacinSulphateNon-Sterial
• AMIKACINSULFATE,USP
• AMIKACIN SULFATE 1:2
• AMIKACIN SULFATE USP JP
• Amikacin Sulfate(Sterile)
• Amikacin Sulfate(Non-Sterile)
• Sterile
• AMIKACIN SULPHATE
• y-alpha-d-glucopyranosyl-(1-4))-n(sup1)-(4-amino-2-hydroxy-1-oxobutyl)-2-deox
• amikacin bis(sulphate)

Amikacin Sulfate

CAS: 39831-55-5

Formula: C₂₂H₄₃N₅O₁₃·2H₂SO₄

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 781.75

Ref: 3B-A2281

Amikacin disulfate

CAS: 39831-55-5

An aminoglycoside antibiotic derived from Kanamycin A

Formula: C₂₂H₄₃N₅O₁₃•2H₂SO₄

Molecular weight: 781.77

Ref: 02-J63862

Amikacin sulfate

CAS: 39831-55-5

Amikacin sulfate

Formula: C₂₂H₄₃N₅O₁₃H₂SO₄

Purity: 89.0%

Color and Shape: White To Off-White

Molecular weight: 683.25312

Ref: 47-853

AMIKACIN SULFATE CRS

CAS: 39831-55-5

AMIKACIN SULFATE CRS

Formula: C₂₂H₄₅N₅O₁₇S

Molecular weight: 683.681

Ref: 41-A0365900

Amikacin Sulfate

CAS: 39831-55-5

Antibiotics nesoi

Formula: C₂₂H₄₃N₅O₁₃·2H₂SO₄

Color and Shape: White Powder

Molecular weight: 585.28574

Ref: 45-1019494

Amikacin Sulfate

CAS: 39831-55-5

Formula: C₂₂H₄₇N₅O₂₁S₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 781.7595

Ref: IN-DA00I7TF

Amikacin disulfate salt

CAS: 39831-55-5

Formula: C₂₂H₄₃N₅O₁₃·2H₂SO₄

Purity: 674 - 786 μg/mg (anhydrous basis, 1:2)

Color and Shape: White to off-white powder

Molecular weight: 781.77

Ref: 7W-GA2441

Amikacin disulphate salt

CAS: 39831-55-5

Amikacin disulphate salt

Formula: C₂₂H₄₃N₅O₁₃·2H₂SO₄

Color and Shape: crystalline powder

Molecular weight: 781.76g/mol

Ref: 54-BIA1010

Amikacin disulfate

CAS: 39831-55-5

Amikacin disulfate

Purity: ≥98%

Molecular weight: 781.76g/mol

Ref: 54-BUP18672

Amikacin Sulfate

CAS: 39831-55-5

Color and Shape: Neat

Ref: 86-MM1279.00

Amikacin disulfate

CAS: 39831-55-5

Amikacin disulfate (BAY-416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.

Formula: C₂₂H₄₃N₅O₁₃·2H₂O₄S

Purity: 98.67% - 99.3%

Color and Shape: White Crystalline Powder From Methanol-Isopropanol Solid

Molecular weight: 781.76

Ref: TM-T6382

Amikacin Sulfate

Controlled Product

CAS: 39831-55-5

Stability Hygroscopic
Applications Semisynthetic aminoglycoside antibiotic derived from Kanamycin A. Antibacterial.
References Cabana, T., et al.: Antimicrob. Agents Chemother., 3, 478 (1973), Cappelletti, L.M., et al.: J. Antibiot., 36, 328 (1983), Monteleone, P.M., et al.: Anal. Profiles Drug Subs., 12, 37 (1983),

Formula: C₂₂H₄₃N₅O₁₃·2H₂O₄S

Color and Shape: White To Off-White

Molecular weight: 781.76

Ref: TR-A578500

Amikacin Disulfate

CAS: 39831-55-5

Formula: C₂₂H₄₃N₅O₁₃(H₂SO₄)

Molecular weight: 585.6 : 2(98.1)

Ref: ST-EA-CP-A190010

Amikacin disulfate

CAS: 39831-55-5

Inhibitor of protein synthesis; aminoglycoside

Formula: C₂₂H₄₃N₅O₁₃·2H₂SO₄

Purity: 674 To 786 Usp U/Mg

Color and Shape: White Powder

Molecular weight: 781.76 g/mol

Ref: 3D-AA17356

Amikacin Sulphate (AMKS)

CAS: 39831-55-5

Formula: C₂₂H₄₃N₅O₁₃·2H₂SO₄

Color and Shape: White, Crystalline powder

Molecular weight: 781.75

Ref: SR-18036

Amikacin sulfate salt (contains 10% H2O)

CAS: 39831-55-5

Formula: C₂₂H₄₇N₅O₂₁S₂

Purity: 95.0%

Color and Shape: Solid, White powder

Molecular weight: 781.75

Ref: 10-F361958

Amikacin-d5 Sulfate

Controlled Product

CAS: 39831-55-5

Formula: C₂₂H₄₂D₅N₅O₂₁S₂

Color and Shape: Neat

Molecular weight: 786.78

Ref: TR-A578502