CAS 39968-33-7

HOAt

Description:

HOAt, or 1-Hydroxy-7-azabenzotriazole, is a chemical compound recognized for its utility in organic synthesis, particularly as a coupling reagent in peptide synthesis. It features a hydroxyl group and an azabenzotriazole moiety, which contributes to its reactivity. HOAt is known for enhancing the efficiency of amide bond formation by stabilizing the activated intermediates, thus facilitating the coupling of carboxylic acids and amines. The compound is typically used in conjunction with other reagents, such as carbodiimides, to promote the formation of amide bonds under mild conditions. Its solubility in organic solvents makes it versatile for various synthetic applications. Additionally, HOAt is appreciated for its ability to minimize side reactions, leading to higher yields of the desired products. Safety considerations should be taken into account when handling HOAt, as with many chemical reagents, including the use of appropriate personal protective equipment and adherence to safety protocols.

Formula: C₅H₄N₄O

InChI: InChI=1S/C5H4N4O/c10-9-5-4(7-8-9)2-1-3-6-5/h1-3,10H

InChI key: InChIKey=FPIRBHDGWMWJEP-UHFFFAOYSA-N

SMILES: ON1C=2C(=CC=CN2)N=N1

Synonyms:

• 1-Hydroxy-1H-v-triazolo[4,5-b]pyridine
• 1-Hydroxyl-7-azabenzotriazole
• 3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridine
• 3-Hydroxytriazolo[4,5-b]pyridine
• 3H-1,2,3-Triazolo[4,5-b]pyridine, 3-hydroxy-
• 3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol
• 7-Aza-1-hydroxybenzotriazole
• Hoat
• N-Hydroxy-7-azabenzotriazole
• [1,2,3]Triazolo[4,5-b]pyridin-3-ol
• 1-Hydroxy-7-azabenzotriazole

HOAT 1M DMA solution

CAS: 39968-33-7

Formula: C₅H₄N₄O

Purity: 99%

Color and Shape: Solid

Molecular weight: 136.1115

Ref: IN-DA0032SC

1-Hydroxy-7-azabenzotriazole solution

CAS: 39968-33-7

1-Hydroxy-7-azabenzotriazole solution

Purity: 99%

Molecular weight: 136.114g/mol

Ref: 54-OR98224

1-Hydroxy-7-azabenzotriazole, 0.6M solution in DMF

CAS: 39968-33-7

Formula: C₅H₄N₄O

Purity: ≥ 99.0%

Color and Shape: Light yellow or light green to dark yellow or dark green liquid

Molecular weight: 136.11

Ref: 7W-GE4091

Olaparib Impurity 18 (HOAT)

CAS: 39968-33-7

Formula: C₅H₄N₄O

Molecular weight: 136.11

Ref: 4Z-O-032020

1-Hydroxy-7-azabenzotriazole(wetted with water >15%)

CAS: 39968-33-7

Applications 1-Hydroxy-7-azabenzotriazole (cas# 39968-33-7) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Formula: C₅H₄N₄O

Color and Shape: White to Pale Brown Solid

Molecular weight: 136.11

Ref: TR-H805070

HOAt - 0.6M in DMF

CAS: 39968-33-7

HOAt is a triazole derivative used in amide coupling chemistry as an additive in combination with coupling agents. The most used coupling reagents with HOAt are the carbodiimides EDCI, DCC and DIC. HOAt is comparable to HOBt but gives a better performance. It has faster reaction rates, reduced racemisation, higher yields and visual indication of the reaction endpoint by colour change of the reaction mixture from yellow to colourless. The increased efficiency of HOAt compared to HOBt is related to the stabilisation of the activated intermediate via anchimeric effect, due to the formation of a hydrogen bond with the N atom in position 7 of the benzotriazole. As is HOBt, HOAt is explosive and is therefore required to be handled carefully.

Formula: C₅H₄N₄O

Purity: Min. 98 Area-%

Color and Shape: Colorless Slightly Yellow Clear Liquid

Molecular weight: 136.11 g/mol

Ref: 3D-FH162259

1-Hydroxy-7-azabenzotriazol, 0.6 M solution in DMF

CAS: 39968-33-7

Please enquire for more information about 1-Hydroxy-7-azabenzotriazol, 0.6 M solution in DMF including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₅H₄N₄O

Molecular weight: 136.11 g/mol

Ref: 3D-W-202647

HOAT (1-Hydroxy-7-azobenzotriazole) pure, 98%

CAS: 39968-33-7

Formula: C₅H₄N₄O

Purity: min. 98%

Color and Shape: White to off-white, Crystalline powder

Molecular weight: 136.11

Ref: SR-81240