CAS 40017-58-1

(2-aminothiophen-3-yl)(2-chlorophenyl)methanone

Description:

(2-aminothiophen-3-yl)(2-chlorophenyl)methanone, with the CAS number 40017-58-1, is an organic compound characterized by the presence of both an amino group and a chlorophenyl moiety attached to a thiophene ring. This compound features a thiophene ring substituted at the 3-position with an amino group, which can impart basic properties and potential reactivity in various chemical reactions. The presence of the chlorophenyl group enhances its lipophilicity and may influence its biological activity. The carbonyl group (ketone) in the methanone structure contributes to the compound's reactivity, making it a potential candidate for further chemical modifications or applications in medicinal chemistry. The compound may exhibit interesting pharmacological properties due to its structural features, which could be explored in drug development or as a lead compound in the synthesis of more complex molecules. Overall, its unique combination of functional groups suggests potential utility in various chemical and biological contexts.

Formula: C₁₁H₈ClNOS

InChI: InChI=1/C11H8ClNOS/c12-9-4-2-1-3-7(9)10(14)8-5-6-15-11(8)13/h1-6H,13H2

InChI key: InChIKey=PYKUZKXKWBHTCO-UHFFFAOYSA-N

SMILES: C(=O)(C1=C(N)SC=C1)C2=C(Cl)C=CC=C2

Synonyms:

• (2-Amino-3-thienyl)(2-chlorophenyl)methanone
• (2-Amino-thiophen-3-yl)-(2-chloro-phenyl)-methanone
• 2-Amino-3-(2-Chlorobenzoyl)Thiophene
• 2-Amino-3-(o-chlorobenzoyl)-thiophene
• Methanone, (2-Amino-3-Thienyl)(2-Chlorophenyl)-
• (2-Aminothiophen-3-yl)-(2-chlorophenyl)methanone

2-Amino-3-(2-chlorobenzoyl)thiophene

Controlled Product

CAS: 40017-58-1

Applications 2-Amino-3-(2-chlorobenzoyl)thiophene is a useful compound for the synthetic process of Brotizolam (B689280(M)), which is a hypnotic and a sedative.
References Du, D. P., et al.: Zhongguo Yaowu Huaxue Zazhi, 25, 280 (2015); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Nishino, T., et al.: J. Pharmacol. Sci., 107, 349 (2008); Yamashiro, T., et al.: J. Clin. Pharm, Ther., 33, 273 (2008); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)

Formula: C₁₁H₈ClNOS

Color and Shape: Neat

Molecular weight: 237.71

Ref: TR-A603480