CAS 4008-48-4

Nitroxoline

Description:

Nitroxoline, with the CAS number 4008-48-4, is a synthetic organic compound primarily used as an antimicrobial agent. It belongs to the class of quinolines and is characterized by its yellow crystalline appearance. Nitroxoline exhibits broad-spectrum antibacterial properties, making it effective against various gram-positive and gram-negative bacteria, as well as certain fungi. Its mechanism of action involves the inhibition of bacterial DNA synthesis and interference with the function of metalloproteins. The compound is soluble in water and alcohol, which facilitates its use in pharmaceutical formulations. Nitroxoline is often utilized in the treatment of urinary tract infections and is known for its relatively low toxicity profile. Additionally, it has been studied for potential applications in other medical fields, including its anticancer properties. However, like any medication, it may have side effects, and its use should be guided by a healthcare professional. Overall, nitroxoline is a valuable compound in the realm of antimicrobial therapy.

Formula: C₉H₆N₂O₃

InChI: InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H

InChI key: InChIKey=RJIWZDNTCBHXAL-UHFFFAOYSA-N

SMILES: N(=O)(=O)C=1C2=C(C(O)=CC1)N=CC=C2

Synonyms:

• 5-(Hydroxyl[oxido]amino)-8-hydroxyquinoline
• 5-Nitro-8-hydroxyquinoline
• 5-Nitro-8-oxychinoline
• 5-Nitro-8-oxyquinoline
• 5-Nitro-8-quinolinol
• 5-Nitrox
• 5-Nitroxine
• 5Nok
• 8-Nitroquinolin-5-Ol
• 8-Quinolinol, 5-nitro-
• A 82
• Bas 58
• Nibiol
• Nitroxolin
• Nitroxolina
• Nitroxoline
• Noxibiol
• Nsc 74947
• Nsc 74948

8-Hydroxy-5-nitroquinoline

CAS: 4008-48-4

Formula: C₉H₆N₂O₃

Purity: >98.0%(GC)(T)

Color and Shape: Light yellow to Brown to Dark green powder to crystal

Molecular weight: 190.16

Ref: 3B-H0805

Nitroxoline

CAS: 4008-48-4

Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in

Formula: C₉H₆N₂O₃

Purity: 97.74% - 99.09%

Color and Shape: Solid

Molecular weight: 190.16

Ref: TM-T0400

8-Hydroxy-5-nitroquinoline

CAS: 4008-48-4

8-Hydroxy-5-nitroquinoline

Formula: C₉H₆N₂O₃

Purity: 98%

Color and Shape: light yellow to khaki solid

Molecular weight: 190.16g/mol

Ref: 54-OR5948

Nitroxoline

CAS: 4008-48-4

Nitroxoline

Purity: ≥95%

Molecular weight: 190.16g/mol

Ref: 54-BUP19192

8-Hydroxy-5-nitroquinoline

CAS: 4008-48-4

Formula: C₉H₆N₂O₃

Purity: ≥ 95.0%

Color and Shape: Pale yellow to dark yellow or beige powder or solid

Molecular weight: 190.16

Ref: 7W-GK4132

Nitroxoline

Controlled Product

CAS: 4008-48-4

Formula: C₉H₆N₂O₃

Color and Shape: Neat

Molecular weight: 190.16

Ref: 04-C15616500

Nitroxoline

Controlled Product

CAS: 4008-48-4

Formula: C₉H₆N₂O₃

Color and Shape: Neat

Molecular weight: 190.16

Ref: 86-MM1003.00

Nitroxoline-d5

CAS: 4008-48-4

Formula: C₉HD₅N₂O₃

Molecular weight: 195.19

Ref: 4Z-N-168002

Nitroxoline

CAS: 4008-48-4

Formula: C₉H₆N₂O₃

Molecular weight: 190.16

Ref: 4Z-N-168001

5-Nitro-8-hydroxyquinoline

Controlled Product

CAS: 4008-48-4

Applications 5-Nitro-8-hydroxyquinoline is an antimicrobial agent used for the treatment of urinary tract infection. 5-Nitro-8-hydroxyquinoline is also a potent and reversible inhibitor of cathepsin B. 5-Nitro-8-hydroxyquinoline has been shown to have anti-cancer activity.
References Mirkovic, B. et al.: ChemMedChem, 6, 1351 (2011): Jiang, H. et al.: Cancer Lett., 312, 11 (2011); Ghoneim, M.M. et al.: Bioelectrochemistry, 80, 162 (2011);

Formula: C₉H₆N₂O₃

Color and Shape: Off White Solid

Molecular weight: 190.16

Ref: TR-N496215

Nitroxoline

CAS: 4008-48-4

Nitroxoline is a compound that inhibits the formation of iron-containing proteins and has been shown to be effective in reducing tumor growth. It has also been shown to reduce the development of resistant mutants in bacteria, as well as inhibiting the production of epithelial mesenchymal markers. Nitroxoline inhibits the polymerase chain reaction (PCR) by blocking DNA synthesis and is being studied for its potential to treat cancer. Nitroxoline was found to inhibit the proliferation of carcinoma cell lines and showed anticancer activity when combined with temozolomide treatment. Nitroxoline is not active against Gram-positive bacteria such as Staphylococcus aureus or Enterococcus faecalis, but it does have antimicrobial effects against Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae, and Klebsiella pneumoniae. Nitroxoline can be used to clean wounds infected with

Formula: C₉H₆N₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 190.16 g/mol

Ref: 3D-FN35484

8-Hydroxy-5-nitroquinoline

CAS: 4008-48-4

Formula: C₉H₆N₂O₃

Purity: 96.0%

Color and Shape: Yellow powder

Molecular weight: 190.158

Ref: 10-F044621

Nitroxoline

CAS: 4008-48-4

Color and Shape: Neat

Ref: 61-FOR1003.00