CAS 401816-26-0

Pyrazolo[1,5-a]pyridine-6-carbonitrile, 2-(4-fluorophenyl)-3-(4-pyridinyl)-

Description:

Pyrazolo[1,5-a]pyridine-6-carbonitrile, 2-(4-fluorophenyl)-3-(4-pyridinyl)-, identified by CAS number 401816-26-0, is a heterocyclic organic compound characterized by its complex structure that includes a pyrazolo-pyridine framework. This compound features a carbonitrile functional group, which contributes to its reactivity and potential applications in various chemical reactions. The presence of a 4-fluorophenyl group and a 4-pyridinyl group enhances its molecular diversity and may influence its biological activity, making it of interest in medicinal chemistry. Pyrazolo[1,5-a]pyridines are known for their potential pharmacological properties, including anti-inflammatory and anti-cancer activities. The compound's solubility, stability, and reactivity can vary based on its substituents and the overall molecular structure. As with many heterocycles, it may exhibit unique electronic properties due to the presence of nitrogen atoms in the ring system, which can affect its interaction with biological targets. Further studies are often required to fully elucidate its properties and potential applications in drug development or other fields.

Formula: C₁₉H₁₁FN₄

Synonyms:

• Pyrazolo[1,5-a]pyridine-6-carbonitrile, 2-(4-fluorophenyl)-3-(4-pyridinyl)-

Yck2-IN-1

CAS: 401816-26-0

Yck2-IN-1 (Compound 2a) is an inhibitor of the fungus Candida albicans Yck2. It has an IC50 of approximately 80 nM for Yck2 and an MIC80 of 12.5 µM for C. albicans, demonstrating good metabolic stability [66% remaining in mouse liver microsomes]. In a mouse model with drug-resistant Candida, Yck2-IN-1 significantly reduced fungal load in the kidneys. Yck2-IN-1 shows potential for research in antifungal infection treatments.

Formula: C₁₉H₁₁FN₄

Color and Shape: Solid

Molecular weight: 314.316

Ref: TM-T206070