CAS 40182-06-7

[1,1′-Biphenyl]-2-sulfonamide

Description:

[1,1′-Biphenyl]-2-sulfonamide, with the CAS number 40182-06-7, is an organic compound characterized by the presence of a biphenyl structure substituted with a sulfonamide group at the 2-position. This compound typically exhibits properties associated with sulfonamides, such as being a solid at room temperature and having moderate solubility in polar solvents due to the sulfonamide functional group. The sulfonamide moiety contributes to its potential as a pharmacophore, making it of interest in medicinal chemistry for its antibacterial and diuretic properties. Additionally, the biphenyl structure can influence the compound's electronic properties and steric hindrance, which may affect its biological activity and interactions with other molecules. The compound may also participate in various chemical reactions, including nucleophilic substitutions and coupling reactions, making it useful in synthetic organic chemistry. Overall, [1,1′-Biphenyl]-2-sulfonamide is a versatile compound with applications in both research and industry, particularly in the development of pharmaceuticals.

Formula: C₁₂H₁₁NO₂S

InChI: InChI=1S/C12H11NO2S/c13-16(14,15)12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9H,(H2,13,14,15)

InChI key: InChIKey=SBXDENYROQKXBE-UHFFFAOYSA-N

SMILES: S(N)(=O)(=O)C1=C(C=CC=C1)C2=CC=CC=C2

Synonyms:

• [1,1′-Biphenyl]-2-sulfonamide
• 2-Phenylbenzene-1-sulfonamide
• 2-Phenylbenzenesulfonamide
• 2-Biphenylsulfonamide

2-Phenylbenzene-1-sulfonamide

CAS: 40182-06-7

2-Phenylbenzene-1-sulfonamide is a biphenyl compound that inhibits the production of endothelin, a peptide hormone that plays a role in regulating blood pressure and blood flow. It has been shown to be effective in vitro against experimental models of congestive heart disease and bowel disease. 2-Phenylbenzene-1-sulfonamide also inhibits the activity of x-ray crystal structures, which are proteins involved in apoptosis or programmed cell death. 2-Phenylbenzene-1-sulfonamide is not active against bacteria, but it has been shown to inhibit Mcl-1 protein, which regulates the process of apoptosis. This drug also has sodium salt forms that are used to treat metabolic disorders such as diabetes mellitus type II.

Formula: C₁₂H₁₁NO₂S

Purity: Min. 95%

Molecular weight: 233.29 g/mol

Ref: 3D-QBA18206